Results 41 to 50 of about 21,633,590 (239)

A Tobacco S-like RNase Inhibits Hyphal Elongation of Plant Pathogens

Molecular Plant-Microbe Interactions, 2002
Ribonuclease (RNase) NE gene expression is induced in tobacco leaves in response to Phytophthora parasitica. Using antibodies directed against RNase NE, we demonstrate that RNase NE is extracellular at the early steps of the interaction, while the fungal
Karine Hugot, Michel Ponchet, Antoine Marais, Pierre Ricci, Eric Galiana   +4 more
doaj   +1 more source

Identification of S-genotypes and a novel S-RNase in 84 native Chinese pear accessions

Horticultural Plant Journal, 2022
The Chinese pear (Pyrus spp.) exhibits typical gametophytic self-incompatibility (GSI), which inhibits self-crossing and promotes out-crossing, similar to other fruit species in the Rosaceae family.
Min He, Lufei Li, Ying Xu, Jianxin Mu, Zhihua Xie, Chao Gu, Shaoling Zhang   +6 more
doaj   +1 more source

CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]

, 2010
The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
María Eugenia Gas López, Bertrand Séraphin, Andrzej Dziembowski, Dziembowski, A, Gas López, Maria Eugenia, Dziembowski, Andrzej, Tomecki, R, Gas Lopez, Maria, Séraphin, Bertrand, Chlebowski, Aleksander, Tomecki, Rafał, Aleksander Chlebowski, Rafał Tomecki, Chlebowski, A   +13 more
core   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Nature Communications, 2020
Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S.
Anna Perederina, Di Li, Hyunwook Lee, Carol Bator, Igor Berezin, Susan L. Hafenstein, Andrey S. Krasilnikov   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Identification of regions in which positive selection may operate in S-RNase of Rosaceae: Implication for S-allele-specific recognition sites in S-RNase [PDF]

, 1998
A stylar S-RNase is associated with gametophytic self-incompatibility in the Rosaceae, Solanaceae, and Scrophulariaceae. This S-RNase is responsible for S-allele-specific recognition in the self-incompatible reaction, but how it functions in specific ...
Endo, Toshinori, Yamaguchi-Kabata, Yumi, Ishimizu, Takeshi, Nakamura, Kazuo T., Sakiyama, Fumio, Fumio Sakiyama, Norioka, Shigemi, Takeshi Ishimizu, Shigemi Norioka, Yumi Yamaguchi-Kabata, Kazuo T. Nakamura, Toshinori Endo   +11 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of S-genotypes of sweet cherry cultivars from Central and Eastern Europe

Horticultural Science, 2015
Sweet cherry is a species that is characterized by self-incompatibility, which causes difficulties in obtaining high yields of sweet cherry fruit. Determination of the composition of the S-alleles of sweet cherry cultivars is useful both to growers ...
A. Lisek, E. Rozpara, A. Głowacka, D. Kucharska, M. Zawadzka   +4 more
doaj   +1 more source