Results 71 to 80 of about 301,171 (270)

A photo-responsive F-box protein FOF2 regulates floral initiation by promoting FLC expression in Arabidopsis. [PDF]

, 2017
Floral initiation is regulated by various genetic pathways in response to light, temperature, hormones and developmental status; however, the molecular mechanisms underlying the interactions between different genetic pathways are not fully understood ...
He, Reqing, Ji, Ronghuan, Li, Hongyu, Li, Xinmei, Li, Xu, Lin, Chentao, Lin, Jianzhong, Liu, Bin, Liu, Hongtao, Liu, Xuanming, Sun, Mengsi, Tang, Dongying, Wang, Qin, Wu, Dan, Yan, Jindong, Zhao, Xiaoying, Zhong, Ming   +16 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Identification of S-genotypes of sweet cherry cultivars from Central and Eastern Europe

Horticultural Science, 2015
Sweet cherry is a species that is characterized by self-incompatibility, which causes difficulties in obtaining high yields of sweet cherry fruit. Determination of the composition of the S-alleles of sweet cherry cultivars is useful both to growers ...
A. Lisek, E. Rozpara, A. Głowacka, D. Kucharska, M. Zawadzka   +4 more
doaj   +1 more source

Caractérisation moléculaire de cinq nouveaux allèles-S liés à l’autoincompatibilité chez des cultivars locaux espagnols d’amandier [PDF]

, 2011
Almond is a highly heterozygous species with a high number of S-alleles controlling its gametophytic self-incompatibility system (GSI). In this work we have analysed Spanish local almond cultivars for S-RNase allele diversity.
Kodad, Ossama, Oliveira, M. Margarida, Saibo, Nelson José, Socias i Company, Rafel, Sánchez, A.   +4 more
core  

Thiol-based redox regulation in sexual plant reproduction: new insights and perspectives [PDF]

, 2013
The success of sexual reproduction in plants involves (i) the proper formation of the plant gametophytes (pollen and embryo sac) containing the gametes, (ii) the accomplishment of specific interactions between pollen grains and the stigma, which ...
Pulido, Amada, Rodríguez García, María I., Traverso, José A.   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Molecular modeling of RNases from almond involved in serlf-incompatibility [PDF]

, 2011
Gametophytic self-incompatibility (GSI) is a natural mechanism in flowering plants, including almond and other fruit tree species, to prevent inbreeding and promote outcrossing. It is typically under the control of a specific locus, known as the S-locus,
Alonso Segura, José Manuel, Fernández i Martí, Angel V., Hrmova, María, Socias i Company, Rafel, Wirthensohn, Michelle   +4 more
core  

The Molecular and Genetic Bases of S-RNase-Based Self-Incompatibility [PDF]

THE PLANT CELL ONLINE, 2004
The majority of flowering plants produce perfect flowers that contain both the male and female reproductive organs in close proximity; consequently, they would have a strong tendency to self-fertilize if there were no mechanisms to prevent them from doing so.
Teh-hui, Kao, Tatsuya, Tsukamoto
openaire   +2 more sources