Results 171 to 180 of about 20,475 (213)

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

Cell, 1994
Shigella species cause bacillary dysentery in humans by invading colonic epithelial cells. IpaB and IpaC, two major invasins of these pathogens, are secreted into the extracellular milieu. We show here that IpaB and IpaC form a complex in the extracellular medium and that each binds independently to a 17 kDa polypeptide, IpgC, in the bacterial ...
R, Ménard, P, Sansonetti, C, Parsot, T, Vasselon   +3 more
openaire   +2 more sources

O-antigen structure of Shigella flexneri serotype Yv and effect of the lpt-O gene variation on phosphoethanolamine modification of S. flexneri O-antigens

Glycobiology, 2013
Shigella flexneri is the major human pathogen causing shigellosis. O-antigens of all S. flexneri serotypes (except for serotype 6) share the →2)-α-l-Rhap(III)-(1 → 2)-α-l-Rhap(II)-(1 → 3)-α-l-Rhap(I)-(1 → 3)-β-d-GlcpNAc-(1→ basic O-unit, whereas differences between the serotypes are conferred by phage-encoded glucosylation and/or O-acetylation at ...
Yuriy A, Knirel, Ruiting, Lan, Sof'ya N, Senchenkova, Jianping, Wang, Alexander S, Shashkov, Yan, Wang, Andrei V, Perepelov, Yanwen, Xiong, Jianguo, Xu, Qiangzheng, Sun   +9 more
openaire   +2 more sources

In silico and in vivo approaches to recombinant multi-epitope immunogen of GroEL provides efficient cross protection against S. Typhimurium, S. flexneri, and S. dysenteriae

Molecular Immunology, 2022
Stress or Heat Shock Proteins (HSPs) have been included in various operations like protein folding, autophagy, and apoptosis. HSP families recognize as protective antigens in a wide range of bacteria because they have been conserved through evolution.
Hassan, Ardestani, Shahram, Nazarian, Abbas, Hajizadeh, Davoud, Sadeghi, Emad, Kordbacheh   +4 more
openaire   +2 more sources

Myosin light chain kinase plays an essential role in S. flexneri dissemination

Journal of Cell Science, 2000
ABSTRACT Shigella flexneri, the causitive agent of bacillary dysentery, has been shown to disseminate in colonic epithelial cells via protrusions that extend from infected cells and are endocytosed by adjacent cells. This phenomenon occurs in the region of the eukaryotic cell’s adherens junctions and is inhibited by pharmacological ...
M, Rathman, P, de Lanerolle, H, Ohayon, P, Gounon, P, Sansonetti   +4 more
openaire   +2 more sources

[Gena types of Shigella enterotoxins of S. flexneri 2a].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2004
To identify homogenous clones of S. flexneri 2a, using gene distribution polymorphism of Shigella enterotoxin 1 (set 1) and Shigella enterotoxin 2 (set 2) in a Shigellosis outbreak caused by S. flexneri 2a.In addition to field epidemiological investigation, 43 strains of S.
S, Bai, X, Li, G, Xia, H, Yuan, W, Zheng, H, Wang   +5 more
openaire   +1 more source

Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen

Vaccine, 1992
The construction and characterization of EcSf2a-2, an aroD-deleted Escherichia coli-Shigella hybrid vaccine carrying chromosomal and plasmid genes from Shigella flexneri and expressing S. flexneri 2a somatic antigen in association with E. coli K12 core are described.
J W, Newland, T L, Hale, S B, Formal
openaire   +2 more sources

Development and evaluation of a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine

Vaccine, 2006
Over 160 million cases of shigellosis occur annually worldwide, with the two most prevalent species being Shigella flexneri and S. sonnei. Protective immunity against Shigella infection is primarily directed at the lipopolysaccharide (LPS) of the homologous serotype, so it may be necessary to combine monovalent vaccines for multiple Shigella serotypes ...
Edwin V, Oaks, K Ross, Turbyfill
openaire   +2 more sources

A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a

Cell, 1986
We have identified a region (virG) on the 230 kb virulence plasmid of S. flexneri that is required for cell-to-cell spread of the bacterium. Tn5 insertions into this region result in avirulent mutants that can initially invade and multiply in epithelial cells, but tend to lose active movement and tend to localize within the cytoplasm, where they are ...
S, Makino, C, Sasakawa, K, Kamata, T, Kurata, M, Yoshikawa   +4 more
openaire   +2 more sources

Experimental keratoconjunctivitis caused by S. flexneri and by its genetic recombinations

Bulletin of Experimental Biology and Medicine, 1964
The presence of pathogenic properties was studied in 50 strains of S. flexneri 5 E. coli cultures and 267 sexual recombination by infection of the guinea pig conjunctiva. As noted, 20 strains of S. flexneri and 39 hybrids induced specific keratoconjunctivitis. Although S.
openaire   +1 more source

Inhibitory effects of spices and herbs towards Shigella sonnei and S. flexneri.

Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen), 2005
The use of spices and herbs, their essential oils or their active compounds as means of control of pathogens constitutes an alternative to chemical additives In the present study the antibacterial activities of cloves, thyme, oregano, rosemary and basil on Shigella have been established.
C F, Bagamboula, M, Uyttendaele, J, Debevere   +2 more
openaire   +1 more source