Results 51 to 60 of about 2,547,606 (153)

CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models

Genes & cancer, 2014
In spite of the efficacy of Her2-targeted therapies, recurrence and progression remain a challenge for treatment of Her2 positive breast cancer. CDK4/6 controls pathway downstream of Her2, Inhibition of these kinases could represent an important ...
A. Witkiewicz, Derek W. Cox, E. Knudsen
semanticscholar   +1 more source

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

OncoTarget, 2016
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The aggressiveness and therapeutic recalcitrance of this malignancy has been attributed to multiple factors including the influence of an active desmoplastic stroma.
E. Knudsen, U. Balaji, Elizaveta Freinkman, P. Mccue, A. Witkiewicz   +4 more
semanticscholar   +1 more source

“Clarity is a Fiction Made of the Fabric of Chaos”: Irzykowski Nonunderstandableness

Zagadnienia Rodzajów Literackich, 2019
https://doi.org/10.26485/ZRL/2018/61.3/5 The paper deals with a famous critical controversy of Poland’s interbellum period, the polemic about what Karol Irzykowski called “nonunderstandableness,” stirred up by his article Niezrozumialstwo (1924 ...
Sylwia Panek
doaj  

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

Cancer Biology & Therapy, 2010
Here, we investigated the possible predictive value of stromal caveolin-1 (Cav-1) as a candidate biomarker for clinical outcome in triple negative (TN) breast cancer patients.
A. Witkiewicz, A. Dasgupta, S. Sammons, O. Er, M. Potoczek, F. Guiles, F. Sotgia, J. Brody, E. Mitchell, M. Lisanti   +9 more
semanticscholar   +1 more source

Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer

Clinical Cancer Research, 2007
Purpose: To assess pathologic complete response (pCR), clinical response, feasibility, safety, and potential predictors of response to preoperative trastuzumab plus vinorelbine in patients with operable, human epidermal growth factor receptor 2 (HER2 ...
Lyndsay Harris, L. Harris, F. You, S. Schnitt, A. Witkiewicz, Xin Lu, D. Sgroi, P. Ryan, S. Come, H. Burstein, B. Lesnikoski, Madhavi Kamma, P. Friedman, R. Gelman, J. D. Iglehart, E. Winer   +15 more
semanticscholar   +1 more source

Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target

Journal of the American College of Surgeons, 2009
Background We recently discovered that the enzyme indoleamine 2,3-dioxygenase (IDO) is overexpressed in primary pancreatic ductal adenocarcinomas (PDA) and in lymph node metastases (J Am Coll Surg. 5:849-54: 2008).
A. Witkiewicz, C. L. Costantino, R. Metz, A. Muller, G. Prendergast, C. Yeo, J. Brody   +6 more
semanticscholar   +1 more source

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Cell Cycle, 2010
Loss of stromal caveolin 1 (Cav-1) is a novel biomarker for cancer-associated fibroblasts that predicts poor clinical outcome in breast cancer and DCIS patients.
U. Martinez-Outschoorn, S. Pavlides, D. Whitaker-Menezes, Kristin M. Daumer, Janet N. Milliman, Barbara Chiavarina, Gemma Migneco, A. Witkiewicz, Maria P. Martinez-Cantarin, N. Flomenberg, A. Howell, R. Pestell, M. Lisanti, F. Sotgia   +13 more
semanticscholar   +1 more source

RB-pathway disruption in breast cancer

Cell Cycle, 2010
In breast cancer, inactivation of the RB tumor suppressor gene is believed to occur via multiple mechanisms to facilitate tumorigenesis. However, the prognostic and predictive value of RB status in disease-specific clinical outcomes has remained ...
A. Ertel, Jeffry Dean, H. Rui, Chengbao Liu, A. Witkiewicz, K. Knudsen, E. Knudsen   +6 more
semanticscholar   +1 more source

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Cell Cycle, 2010
We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer patient tumor recurrence, metastasis, tamoxifen-resistance, and poor ...
G. Bonuccelli, D. Whitaker-Menezes, Remedios Castelló-Cros, S. Pavlides, R. Pestell, A. Fatatis, A. Witkiewicz, M. V. Vander Heiden, Gemma Migneco, Barbara Chiavarina, P. G. Frank, F. Capozza, N. Flomenberg, U. Martinez-Outschoorn, F. Sotgia, M. Lisanti   +15 more
semanticscholar   +1 more source

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

OncoTarget, 2015
Pancreatic ductal adenocarcinoma (PDA) harbors an exceedingly poor prognosis, and is generally considered a therapy-recalcitrant disease due to poor response to conventional chemotherapy coupled with non-actionable genetic drivers (e.g.
A. Witkiewicz, Nicholas A. Borja, J. Franco, J. Brody, C. Yeo, J. Mansour, M. Choti, P. Mccue, E. Knudsen   +8 more
semanticscholar   +1 more source