Results 31 to 40 of about 2,547,606 (153)

Metabolic re-programming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities

Cell Reports, 2016
Due to loss of p16ink4a in pancreatic ductal adenocarcinoma (PDA), pharmacological suppression of CDK4/6 could represent a potent target for treatment. In PDA models CDK4/6 inhibition had variable effect on cell cycle, but yielded accumulation of ATP and
J. Franco, U. Balaji, Elizaveta Freinkman, A. Witkiewicz, Erik S. Knudsen   +4 more
semanticscholar   +1 more source

Phase I clinical trial of combination propranolol and pembrolizumab in locally advanced and metastatic melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity

Clinical Cancer Research, 2020
Purpose: Increased β-adrenergic receptor (β-AR) signaling has been shown to promote the creation of an immunosuppressive tumor microenvironment (TME). Preclinical studies have shown that abrogation of this signaling pathway, particularly β2-AR, provides ...
S. Gandhi, M. Pandey, K. Attwood, Wenyan Ji, A. Witkiewicz, E. Knudsen, Cheryl L. Allen, J. Tario, P. Wallace, Carlos Cedeno, M. Levis, S. Stack, P. Funchain, J. Drabick, Mark J. Bucsek, I. Puzanov, H. Mohammadpour, E. Repasky, M. Ernstoff   +18 more
semanticscholar   +1 more source

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

Cell Reports, 2018
SUMMARY Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention.
A. Witkiewicz, Sejin Chung, R. Brough, Paris Vail, J. Franco, C. Lord, E. Knudsen   +6 more
semanticscholar   +1 more source

UEG Week 2023 Poster Presentations

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 535-1498, October 2023.
wiley   +1 more source

Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility

Gut, 2017
Objective Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for ...
E. Knudsen, U. Balaji, B. Mannakee, Paris Vail, C. Eslinger, Christopher Moxom, J. Mansour, A. Witkiewicz   +7 more
semanticscholar   +1 more source

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Cell Reports, 2016
Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance.
A. Witkiewicz, U. Balaji, C. Eslinger, E. McMillan, B. Posner, G. Mills, E. O’Reilly, E. Knudsen   +7 more
semanticscholar   +1 more source

UEG Week 2022 Poster Presentations

, 2022
United European Gastroenterology Journal, Volume 10, Issue S8, Page 473-1092, October 2022.
wiley   +1 more source

Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

Cancer Research, 2017
Acquired resistance to CDK4/6 small molecule inhibitors in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we used a kinome-wide siRNA screen to identify kinases which when downregulated yields sensitivity to the CDK4/
V. Jansen, N. Bhola, Joshua A. Bauer, L. Formisano, Kyung-min Lee, K. Hutchinson, A. Witkiewicz, Preston D. Moore, M. V. Estrada, V. Sanchez, P. G. Ericsson, M. Sanders, P. Pohlmann, M. Pishvaian, David A Riddle, T. Dugger, Wenyi Wei, E. Knudsen, C. Arteaga   +18 more
semanticscholar   +1 more source

Acetylcholinesterase: Structure, dynamics, and interactions with organophosphorus compounds

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Acetylcholinesterase (AChE) is an enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh), removing it from the synaptic cleft after the transmission of an electrical signal, making it an essential component of chemical neurotransmission. AChE is a serine hydrolase, containing a catalytic triad of Ser/His/Glu.
Li‐Wei Hung, Karissa Y. Sanbonmatsu, Robert F. Williams, Julian C.‐H. Chen   +3 more
wiley   +1 more source

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

Cell Cycle, 2011
We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting nutrients from normal host cells, such as fibroblasts, via the secretion of ...
D. Whitaker-Menezes, U. Martinez-Outschoorn, N. Flomenberg, R. Birbe, A. Witkiewicz, A. Howell, S. Pavlides, Aristotelis Tsirigos, A. Ertel, R. Pestell, P. Broda, C. Minetti, M. Lisanti, F. Sotgia   +13 more
semanticscholar   +1 more source