Results 41 to 50 of about 2,547,606 (153)

The role of the brain–gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders

Brain and Behavior, Volume 9, Issue 11, November 2019., 2019
Gut microbiota are proposed to influence mood, cognition, and behavior both directly and indirectly. This offers a new approach to conceptualizing psychological disorders from predisposition through to treatment. While not suggesting that targeting the gut microbiota is the panacea to all psychological conditions, it does offer an exciting new arm to a
Michael Ganci, Emra Suleyman, Henry Butt, Michelle Ball   +3 more
wiley   +1 more source

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

OncoTarget, 2014
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, in part, due to the therapy-recalcitrant nature of the disease. Loss of the CDK4/6 inhibitor CDKN2A is a signature genetic event in PDA.
J. Franco, A. Witkiewicz, E. Knudsen
semanticscholar   +1 more source

Functional determinants of cell-cycle plasticity and sensitivity to CDK4/6 inhibition

Cancer Research, 2020
This work provides a mechanistic insight toward understanding the functional roles of multiple cell cycle regulators that drive plasticity and sensitivity to CDK4/6 inhibition. Intrinsic or acquired resistance to clinically approved CDK4/6 inhibitors has
V. Kumarasamy, Paris Vail, Ram Nambiar, A. Witkiewicz, E. Knudsen   +4 more
semanticscholar   +1 more source

Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Preservation of mobility independence is a primary goal in older adults with physical frailty and sarcopenia (PF&S). Interventions based on the combination of physical activity (PA) and nutritional counselling have been indicated as strategies for the management of this condition, although their effectiveness is not confirmed in all
Alejandro Álvarez‐Bustos, Helio José Coelho‐Junior, Riccardo Calvani, Leocadio Rodriguez‐Mañas, Matteo Tosato, Matteo Cesari, Antonio Cherubini, Alfonso J. Cruz‐Jentoft, Pálmi V. Jónsson, Fabrizia Lattanzio, Marcello Maggio, Regina Roller‐Wirnsberger, Ingrid Rýznarová, Annemie M. W. J. Schols, Cornel C. Sieber, Alan J. Sinclair, Anna Skalska, Timo Strandberg, Achille Tchalla, Eva Topinková, Bruno Vellas, Stephan von Haehling, Francesco Landi, Emanuele Marzetti, for the SPRINTT consortium   +24 more
wiley   +1 more source

UEG Week 2021 Oral Presentations

, 2021
United European Gastroenterology Journal, Volume 9, Issue S8, Page 7-161, October 2021.
wiley   +1 more source

Differences in gene expression between high‐grade dysplasia and invasive HPV+ and HPV− tonsillar and base of tongue cancer

Cancer Medicine, Volume 8, Issue 14, Page 6221-6232, October 2019., 2019
It is debated if high‐grade dysplasia exists in HPV+ TSCC/BOTSCC, there is also a need for pathological invasion markers in HNSCC. Here we present similarities between HPV+ and HPV‐ high‐grade dysplasia, suggesting HPV+ high‐grade dysplasia is an entity. We also identify possible invasion markers in HNSCC. Abstract Background Human papillomavirus (HPV)
Linnea Haeggblom, Andreas Ährlund‐Richter, Leila Mirzaie, Pedro Farrajota Neves da Silva, Ramona G. Ursu, Torbjörn Ramqvist, Anders Näsman   +6 more
wiley   +1 more source

Exploring the Common Mutational Landscape in Cutaneous Melanoma and Pancreatic Cancer

Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.
ABSTRACT Cutaneous melanoma (CM) and pancreatic cancer are aggressive tumors whose incidences are rapidly increasing in the last years. This review aims to provide a complete and update description about mutational landscape in CM and pancreatic cancer, focusing on similarities of these two apparently so different tumors in terms of site, type of cell ...
Elisabetta Broseghini, Federico Venturi, Giulia Veronesi, Biagio Scotti, Marina Migliori, Desy Marini, Claudio Ricci, Riccardo Casadei, Manuela Ferracin, Emi Dika   +9 more
wiley   +1 more source

Immunological and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease

Clinical Cancer Research, 2016
Purpose: Pancreatic ductal adenocarcinoma (PDA) is associated with an immunosuppressive microenvironment that supports the growth of the malignancy as well as immune system evasion.
Jack Hutcheson, U. Balaji, M. Porembka, Megan B. Wachsmann, P. Mccue, E. Knudsen, A. Witkiewicz   +6 more
semanticscholar   +1 more source

Grandezas e fronteiras do ego. A revolta da unidade em S. I. Witkiewicz

Organon, 2005
En proposant une lecture du roman L’inassouvissement, de l’écrivainpolonais Stanislwa Ignacy Witkiewicz, l’auteur analyse le rapport entrel’individu et le collectif pour montrer qu’ils n’appartiennent pas à un ordrereprésentationnel du politique. Le moi se donne à travers plusieurs figuressymboliques qui s’intègrent à une historiosophie catastrophiste ...
openaire   +3 more sources

Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions

Breast Cancer Research, 2014
A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic ...
A. Witkiewicz, E. Knudsen
semanticscholar   +1 more source