Results 21 to 30 of about 2,547,606 (153)

The Colourful Space of Pure Form. The Problem of Colour in Theory and Practice in the Work of Stanisław Ignacy Witkiewicz

Przestrzenie Teorii, 2010
Colour was a very important problem in the whole work of Stanisław Ignacy Witkiewicz. Not only a whole chapter of his basic theoretical work Nowe formy w malarstwie (New Forms in Painting, published 1919) was devoted to that but the artist also examined ...
Anna Żakiewicz
doaj   +1 more source

Music as Pure Art. Stanisław Ignacy Witkiewicz and Konstanty Regamey

Przestrzenie Teorii, 2010
In Witkacy’s aesthetics, the problem of the essence, function and status of music in the system of pure arts has never been finally resolved. Many important questions remained unanswered.
Lech Sokół
doaj   +1 more source

Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunological Markers

Clinical Cancer Research, 2017
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with an immunosuppressive milieu that supports immune system evasion and disease progression.
E. Knudsen, Paris Vail, U. Balaji, H. Ngo, I. Botros, V. Makarov, N. Riaz, V. Balachandran, S. Leach, D. Thompson, T. Chan, A. Witkiewicz   +11 more
semanticscholar   +1 more source

Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression. [PDF]

Cancer Discov
The tumor microenvironment (TME) profoundly influences tumorigenesis, with gene expression in the breast TME capable of predicting clinical outcomes. The TME is complex and includes distinct cancer-associated fibroblast (CAF) subtypes whose contribution ...
Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, Delgado AP, Luo X, Bagchi SM, Belle JI, Campos E, Friedman M, Veis DJ, Knudsen ES, Witkiewicz AK, Powers S, Longmore GD, DeNardo DG, Stewart SA.   +18 more
europepmc   +2 more sources

Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Gut, 2020
Objective This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer.
E. Knudsen, V. Kumarasamy, Sejin Chung, A. Ruiz, Paris Vail, S. Tzetzo, Jin Wu, Ram Nambiar, J. Sivinski, S. Chauhan, M. Seshadri, S. Abrams, Jianmin Wang, A. Witkiewicz   +13 more
semanticscholar   +1 more source

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

Cell Cycle, 2010
Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of poor prognosis in human breast cancer patients, and is associated with early tumor recurrence, lymph node metastasis, and tamoxifen-resistance.
U. Martinez-Outschoorn, Renee M. Balliet, Dayana B. Rivadeneira, Barbara Chiavarina, S. Pavlides, Chenguang Wang, D. Whitaker-Menezes, Kristin M. Daumer, Zhao Lin, A. Witkiewicz, N. Flomenberg, A. Howell, R. Pestell, E. Knudsen, F. Sotgia, M. Lisanti   +15 more
semanticscholar   +1 more source

Gene signature‐based prediction of triple‐negative breast cancer patient response to Neoadjuvant chemotherapy

Cancer Medicine, Volume 9, Issue 17, Page 6281-6295, September 2020., 2020
We developed a framework for identifying a predictive gene signature in breast cancer and defined two gene signatures that could be used to predict NCT response in ER‐positive and TNBC patients, respectively.We have demonstrated that the RPS performed at a comparable level to the current commercialized signatures, while the TNBC‐RPS outperformed 143 ...
Yanding Zhao, Evelien Schaafsma, Chao Cheng   +2 more
wiley   +1 more source

Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma

International Journal of Cancer, Volume 146, Issue 5, Page 1445-1456, 1 March 2020., 2020
Circulating tumor DNA (ctDNA) is assumed to reflect tumor burden and has been suggested as a tool for prognostication and follow‐up in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). However, the prognostic value of ctDNA and its relation with tumor burden has yet to be substantiated, especially in mPDAC.
Marin Strijker, Eline C. Soer, Matteo de Pastena, Aafke Creemers, Alberto Balduzzi, Jamie J. Beagan, Olivier R. Busch, Otto M. van Delden, Hans Halfwerk, Jeanin E. van Hooft, Krijn P. van Lienden, Giovanni Marchegiani, Sybren L. Meijer, Carel J. van Noesel, Roy J. Reinten, Eva Roos, Sandor Schokker, Joanne Verheij, Marc J. van de Vijver, Cynthia Waasdorp, Johanna W. Wilmink, Bauke Ylstra, Marc G. Besselink, Maarten F. Bijlsma, Frederike Dijk, Hanneke W. van Laarhoven   +25 more
wiley   +1 more source

p27 Allosterically Activates Cyclin-Dependent Kinase 4 and Antagonizes Palbociclib Inhibition

Science, 2019
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy.
Keelan G. Guiley, J. W. Stevenson, Kevin Lou, Krister J. Barkovich, V. Kumarasamy, Tilini U. Wijeratne, K. Bunch, S. Tripathi, E. Knudsen, A. Witkiewicz, K. Shokat, S. M. Rubin   +11 more
semanticscholar   +1 more source

Autophagy in cancer associated fibroblasts promotes tumor cell survival

Cell Cycle, 2010
Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the autophagic/lysosomal degradation of stromal caveolin-1 (Cav-1).
U. Martinez-Outschoorn, C. Trimmer, Zhao Lin, D. Whitaker-Menezes, Barbara Chiavarina, Jie Zhou, Chenguang Wang, S. Pavlides, Maria P. Martinez-Cantarin, F. Capozza, A. Witkiewicz, N. Flomenberg, A. Howell, R. Pestell, J. Caro, M. Lisanti, F. Sotgia   +16 more
semanticscholar   +1 more source