Determinants of response to CDK4/6 inhibitors in the real-world setting
npj Precision Oncology, 2023 Despite widespread use and a known mechanism of action for CDK4/6 inhibitors in combination with endocrine therapy, features of disease evolution and determinants of therapeutic response in the real-world setting remain unclear.
A. Witkiewicz +6 more
semanticscholar +1 more source
TP53 mutation is associated with improved disease control in patients with advanced RAS wild-type colorectal adenocarcinoma treated with cetuximab and pembrolizumab. [PDF]
Int J CancerImmunotherapy with checkpoint inhibitors targeting the PD1/PD‐L1 and CTLA4 pathways has limited activity in patients with microsatellite stable (MSS) colorectal adenocarcinoma (CRC). In a prior study, the combination of cetuximab and pembrolizumab failed
Fountzilas C +24 more
europepmc +2 more sources
Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy
Trends in Cancer, 2022 The mammalian cell cycle has been extensively studied regarding cancer etiology, progression, and therapeutic intervention. The canonical cell cycle framework is supported by a plethora of data pointing to a relatively simple linear pathway in which ...
A. Witkiewicz +3 more
semanticscholar +1 more source
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial. [PDF]
Nat CommunCDK4/6 inhibitors (CDK4/6i) improve outcomes for estrogen receptor (ER) positive/HER2-negative breast cancers (BCs), yet intrinsic and acquired resistance exist.
Kong T +33 more
europepmc +2 more sources
The history and future of targeting cyclin-dependent kinases in cancer therapy
Nature reviews. Drug discovery, 2015 Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies.
U. Asghar +3 more
semanticscholar +1 more source
[“Witkacy darted like a gap-toothed person onto rusk”. Witkiewicz during the First World War
Przestrzenie Teorii, 2010 This text is a polemic with an article by Maria A. Potocka “Ja” jako materiał twórczy [“I”as a material for creation]. When considering the problem of the presence of Witkacy in the Tsarist army, the author comes to a conclusion that Witkiewicz went ...
Stefan Okołowicz
doaj +1 more source
The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Cell Cycle, 2009 Here, we propose a new model for understanding the Warburg effect in tumor metabolism. Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in neighboring stromal fibroblasts.
S. Pavlides +13 more
semanticscholar +1 more source
Witkacy’s Attempt at a Subject – a Subject for a Test
Przestrzenie Teorii, 2010 In the article Witkacego próba podmiotu – podmiot na próbę [Witkacy’s Attempt at a Subject – a Subject for a Test] the subjective identity of S.I. Witkiewicz is characterised by means of the widely understood category of a trial.
Irena Górska
doaj +1 more source
Torments of Education (“Metaphysics of a Two-Headed Calf” by S.I. Witkiewicz)
Przestrzenie Teorii, 2010 Identity crisis, one of the crucial problems tackled by Witkacy in his dramas, is linked first of all with the tradition of modernism by critics. The author of the article suggests a change in the viewpoint, and basing on the analysis of Metaphysics of a
Ewa Wąchocka
doaj +1 more source
Cell, 2014 SUMMARY Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression.
S. Comerford +13 more
semanticscholar +1 more source