Results 151 to 160 of about 131,599 (329)

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, EarlyView.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

EGFRvIII Mediates Hepatocellular Carcinoma Cell Invasion by Promoting S100 Calcium Binding Protein A11 Expression

, 2013
Xiaoying Luo, Hailong Xie, Xiaolan Long, Min Zhou, Zhibin Xu, Bizhi Shi, Hua Jiang, Zonghai Li   +7 more
openalex   +2 more sources

IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1 [PDF]

, 2013
Bijoy Chellan, Ling Yan, Timothy J. Sontag, Catherine A. Reardon, Marion A. Hofmann Bowman   +4 more
openalex   +1 more source

Diagnostic and therapeutic approaches of para‐testicular SCRMS in an adolescent patient: A case report

UroPrecision, EarlyView.
Abstract Background Para‐testicular rhabdomyosarcoma (RMS) is a rare and aggressive malignancy primarily affecting children and adolescents, with peak incidence between ages 2 and 5 years. Of the histological variants of RMS, the spindle cell type of RMS is particularly uncommon, accounting for approximately 5% of cases.
Kholoud Alabassi, Yaser M. Ata, Khaled Murshed, Ibrahim A. Khalil, Noheir M. Taha, Khalid Al Rumaihi   +5 more
wiley   +1 more source

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells [PDF]

, 2015
Jyoti K. Jaiswal, Jesper Nylandsted
openalex   +1 more source

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

VIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa, Laura Palumbo, Martina La Rosa, Antonella Girgenti, Fabio Salvatore Palumbo, Pasquale Picone, Francesco Lopresti, Domenico Nuzzo, Vincenzo La Carruba   +8 more
wiley   +1 more source

S100 proteins as a key immunoregulatory mechanism for NLRP3 inflammasome [PDF]

Shahinur Acter, Qing Lin
openalex   +1 more source

Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration [PDF]

, 2019
Shungo Komichi, Yusuke Takahashi, Motoki Okamoto, Manahil Ali, Masakatsu Watanabe, Hailing Huang, Takeo Nakai, Paul R. Cooper, Mikako Hayashi   +8 more
openalex   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release [PDF]

, 2020
Yanfei Ding, Cheng Dou, Shuyue Chang, Zhengming Xie, Deng‐Guang Yu, Yanan Liu, Jun Peng Shao   +6 more
openalex   +1 more source