Results 41 to 50 of about 65,795 (216)

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Promiscuity mapping of the S100 protein family using a high-throughput holdup assay

Scientific Reports, 2022
S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon, Éva Bartus, Beáta Mag, Eszter Boros, Lea Roszjár, Gergő Gógl, Gilles Travé, Tamás A. Martinek, László Nyitray   +8 more
doaj   +1 more source

Self‐Healing Pd(II) Cage Metallogels for Iodine Capture in Water and Heterogeneous Photocatalysis

Advanced Science, EarlyView.
Two carbazole‐derived metal‐organic cages hierarchically self‐assemble into supramolecular metallogels that integrate autonomous self‐healing, reversible stimuli responsiveness, high‐capacity aqueous iodine capture, and visible‐light‐driven photocatalytic sulfide oxidation within a single multifunctional platform.
Monotosh Dalapati, Raghunath Singha, Debashree Manna, Dipak Samanta   +3 more
wiley   +1 more source

Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats

Reproductive Biology and Endocrinology, 2011
Background Mating changes the mechanism by which E2 regulates oviductal egg transport, from a non-genomic to a genomic mode. Previously, we found that E2 increased the expression of several genes in the oviduct of mated rats, but not in unmated rats ...
Croxatto Horacio B, Velásquez Luis A, Parada-Bustamante Alexis, Ríos Mariana, Orihuela Pedro A   +4 more
doaj   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

A case of large diffuse cutaneous neurofibroma masquerading as plexiform variant: Diagnostic challenges [PDF]

Journal of Krishna Institute of Medical Sciences University
Diffuse Cutaneous Neurofibroma (DCN) is an infrequently encountered clinical entity that can be challenging to diagnose due to its variable clinical presentation, radiological findings, and histopathological features.
Shivani S Rao , Ranjana S Ranade
doaj  

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

An integrated biomarker-based prognostic scale for assessing the risk of severe COVID-19 in children

Zdorovʹe Rebenka
Background. Despite available data, the problem of early prediction of COVID-19 severity in the pediatric population remains unresolved. The purpose was to assess the prognostic significance of NSE, S100, IFABP, NGAL, and E-selectin biomar­kers in ...
V.V. Yevtushenko, S.O. Kramarov, I.Yu. Seriakova, L.O. Palatna, M.O. Dudnikova   +4 more
doaj   +1 more source

Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells

Brain Sciences, 2019
Astrogliosis is a pathological process that affects the density, morphology, and function of astrocytes. It is a common feature of brain trauma, autoimmune diseases, and neurodegeneration including spinocerebellar ataxia type 1 (SCA1), a poorly ...
Olga S. Belozor, Dariya A. Yakovleva, Ilya V. Potapenko, Andrey N. Shuvaev, Marina V. Smolnikova, Alex Vasilev, Elena A. Pozhilenkova, Anton N. Shuvaev   +7 more
doaj   +1 more source

S100 Proteins in Acute Myeloid Leukemia

Neoplasia: An International Journal for Oncology Research, 2018
The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell proliferation, cell differentiation, regulation of transcription factors, inflammation, chemotaxis,
Annette K. Brenner, Øystein Bruserud
doaj   +1 more source