Translational Oncology, 2021 Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis. Antigen-presenting dendritic cells (DCs) play a central role in antitumor immunity. DCs expressing CD1a (CD1a-DCs) are considered immature DCs.
Keita Kai, Takao Ide
exaly +3 more sources
Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases [PDF]
Cancer Immunology, ImmunotherapyThe prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired liver metastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and mature CD208+ subsets across anatomical compartments and synchronous ...
Sergii Pavlov +9 more
doaj +2 more sources
Outcomes of pediatric and adult patients with relapsed/refractory cortical (CD1a+) T-cell acute lymphoblastic leukemia. The Spanish experience from SEHOP and PETHEMA groups [PDF]
Annals of HematologyPatients with relapsed/refractory T-cell acute lymphoblastic leukemia (R/R T-ALL) have very poor prognosis. CAR T-cell therapy is being explored in these patients with encouraging results.
Cristina Rivera-Pérez +19 more
doaj +2 more sources
Polymorphism Analysis of NOTCH2 and CD1A Genes and Their Association with Wool Traits in Subo Merino Sheep [PDF]
BiologyTo identify molecular markers associated with wool traits in fine-wool sheep, we examined genetic polymorphisms in the NOTCH2 and CD1A genes in 944 Subo Merino sheep in this study. Subsequently, we performed association analyses between mutation sites in
Shengchao Ma +7 more
doaj +2 more sources
Indeterminate dendritic cell tumor (IDCT) [PDF]
Vestnik Dermatologii i Venerologii, 2023 Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women.
Evgenia V. Okladnikova +4 more
doaj +1 more source
Intradermally Administered Retinoic Acid or Vitamin D3-Loaded Liposomes Induce Tolerogenic Skin Dendritic Cells [PDF]
Journal of Immunology ResearchIn vivo targeting of dendritic cells (DCs) with nanocarriers containing tolerogenic adjuvants is an attractive strategy to dampen inflammation. Here, we used ex vivo skin vaccination to examine the effect of intradermal injection of liposomes loaded with
Noémi Anna Nagy +9 more
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Adult-onset of Langerhans cell histiocytosis: a clinical case
Alʹmanah Kliničeskoj Mediciny, 2021 Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses.
Olga V. Chernysheva +3 more
doaj +1 more source
Expression and significance of dendritic cell markers CD123, FXⅢA and CD1a in leprosy lesions
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To explore the role of dendritic cells in the pathogenesis of leprosy. Method: The expression of three dendritic cell markers (CD123, FXⅢA, CD1a) in leprosy lesions was assessed by immunohistochemical staining, and their significance was ...
Wenjun ZHOU, Yan QIN
doaj +1 more source
Langerhans Cell Expression in Oral Submucous Fibrosis: An Immunohistochemical Analysis [PDF]
Journal of Clinical and Diagnostic Research, 2015 Background: Langerhans cells (LCs), are dendritic cells of the epithelium which play a role in an array of oral lesions from gingivitis to oral cancer.
Bharghavi Narayanan, Malathi Narasimhan
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Cerebral CD1a positive Rosai–Dorfman disease with coexistent granulomatous angiitis: A case report
Glioma, 2022 Rosai–Dorfman disease (RDD) is a nonneoplastic histiocytic proliferation. RDD is CD1a negative as opposed to Langerhans cell histiocytosis (LCH). The lesion was positive for CD1a immunohistochemistry in our RDD patient, suggesting an overlap with LCH. In
Sweety Vijay Shinde, Asha Sharad Shenoy
doaj +1 more source