Results 11 to 20 of about 21,316 (223)
CD1a promotes systemic manifestations of skin inflammation
Nature Communications, 2022 Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and ...
Clare S. Hardman +15 more
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CD1a autoreactivity: When size does matter [PDF]
Journal of Experimental Medicine, 2021 CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but ...
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The Korean Journal of Gastroenterology, 2022 Langerhans cell histiocytosis (LCH) is reported less frequently in adults than in children. The most common site of involvement in adults is the bone, accounting for 30-50% of cases. The gastrointestinal tract is very rare, accounting for approximately 2%
Seong Je Kim +8 more
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CD1a function in human skin disease
Molecular Immunology, 2021 The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely ...
Annemieke de Jong, Graham Ogg
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Journal for ImmunoTherapy of Cancer, 2022 Background The dismal clinical outcome of relapsed/refractory (R/R) T cell acute lymphoblastic leukemia (T-ALL) highlights the need for innovative targeted therapies.
Pablo Menendez +12 more
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Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
Frontiers in Immunology, 2021 Langerhans cell histiocytosis lesions are characterized by CD1a+ myeloid lineage LCH cells and an inflammatory infiltrate of cytokines and immune cells, including T cells.
Jenée Mitchell +2 more
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Isolated Langerhans Histiocytosis in Thyroid: Thyroidectomy or Chemotherapy? [PDF]
Journal of Clinical and Diagnostic Research, 2015 Langerhans cell histiocytosis (LCH) is a rare disorder of mononuclear phagocytic system whose clinical presentation varies from the localised involvement of a single bone to a widely disseminated disease.
Anoop Attakkil +4 more
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CD1a Reactivity in Non-neoplastic Adenohypophysis [PDF]
American Journal of Surgical Pathology, 2016 Within the differential diagnosis of patients presenting with sellar or suprasellar lesions is Langerhans cell histiocytosis (LCH). CD1a staining is frequently used to identify the presence of an abnormal proliferation of Langerhans cells on histologic sections and contributes to the diagnosis of LCH.
David J, Pisapia +2 more
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Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells
Blood Advances, 2020 : Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder that is characterized by the inflammatory lesions with pathogenic CD1a+CD207+ dendritic cells (DCs). BRAFV600E and other somatic activating MAPK gene mutations have been identified in
Karen Phaik Har Lim +19 more
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Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions. [PDF]
PLoS ONE, 2014 Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease.
Jennifer A West +8 more
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