Results 11 to 20 of about 15,640 (205)
CD1a promotes systemic manifestations of skin inflammation [PDF]
Nature Communications, 2022 Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and ...
Clare S. Hardman +15 more
doaj +4 more sources
It is time to beelieve the CD1a hype! [PDF]
European Journal of Immunology, 2016 Conventional T cells have historically been linked to exacerbating allergy. By efficiently generating primarily TH2 cells, allergens skew the immune response to produce IL‐4, IL‐13, and IgE. Previously, CD1a‐responsive T cells were shown to functionally respond to bee and wasp venom allergens.
Sai Harsha, Krovi, Laurent, Gapin
core +8 more sources
Molecular Mechanism of Lipopeptide Presentation by CD1a [PDF]
Immunity, 2005 CD1a is expressed on Langerhans cells (LCs) and dendritic cells (DCs), where it mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains. We demonstrate here that CD1a-restricted T cells can discriminate the peptide component of didehydroxymycobactin lipopeptides.
Zajonc, Dirk M. +12 more
core +6 more sources
Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells [PDF]
Blood Advances, 2020 : Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder that is characterized by the inflammatory lesions with pathogenic CD1a+CD207+ dendritic cells (DCs). BRAFV600E and other somatic activating MAPK gene mutations have been identified in
Karen Phaik Har Lim +19 more
doaj +7 more sources
Translational Oncology, 2021 Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis. Antigen-presenting dendritic cells (DCs) play a central role in antitumor immunity. DCs expressing CD1a (CD1a-DCs) are considered immature DCs.
Shinichi Aishima, Keita Kai, Takao Ide
exaly +3 more sources
Cracking the code of skin inflammation with CD1a [PDF]
Nature Immunology, 2016 CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact dermatitis as well as in psoriasis.
Kim, Ji Hyung +11 more
core +8 more sources
CD1a Expression in Oral Dysplastic Lesions: An Immunohistochemical Analysis [PDF]
Journal of DentistryBackground: Leukoplakia is among the most prevalent oral potentially malignant disorders, and its association with oral epithelial dysplasia (OED) markedly increases the risk of malignant transformation.
Parsa Eftekhari-Moghadam +1 more
doaj +2 more sources
Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis? [PDF]
Frontiers in Immunology, 2021 Langerhans cell histiocytosis lesions are characterized by CD1a+ myeloid lineage LCH cells and an inflammatory infiltrate of cytokines and immune cells, including T cells.
Jenée Mitchell +2 more
doaj +2 more sources
Outcomes of pediatric and adult patients with relapsed/refractory cortical (CD1a+) T-cell acute lymphoblastic leukemia. The Spanish experience from SEHOP and PETHEMA groups [PDF]
Annals of HematologyPatients with relapsed/refractory T-cell acute lymphoblastic leukemia (R/R T-ALL) have very poor prognosis. CAR T-cell therapy is being explored in these patients with encouraging results.
Cristina Rivera-Pérez +19 more
doaj +2 more sources
CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis. [PDF]
Inflammatory Bowel Diseases, 2018 CD1a-expressing CD14+ monocytes have been identified as inducers of autoreactive T cells. In this study, the link between inflammatory and metabolic signals and CD1a-expressing monocytes in vitro and in vivo was examined, and CD1a was evaluated as a potential therapeutic target for treatment of ulcerative colitis (UC).Peripheral blood mononuclear cells
Matthias Siebeck +2 more
exaly +3 more sources