Results 41 to 50 of about 15,640 (205)

CD1a Reactivity in Non-neoplastic Adenohypophysis [PDF]

American Journal of Surgical Pathology, 2016
Within the differential diagnosis of patients presenting with sellar or suprasellar lesions is Langerhans cell histiocytosis (LCH). CD1a staining is frequently used to identify the presence of an abnormal proliferation of Langerhans cells on histologic sections and contributes to the diagnosis of LCH.
David J, Pisapia, Marc K, Rosenblum, Ehud, Lavi   +2 more
openaire   +2 more sources

A polymorphism in human CD1A is associated with susceptibility to tuberculosis [PDF]

Genes & Immunity, 2014
CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease.
Seshadri, C, Thuong, NTT, Yen, NTB, Bang, ND, Chau, TTH, Thwaites, GE, Dunstan, SJ, Hawn, TR   +7 more
openaire   +5 more sources

Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis. [PDF]

PLoS ONE, 2012
BACKGROUND: Sepsis is a multifactorial pathology with high susceptibility to secondary infections. Innate and adaptive immunity are affected in sepsis, including monocyte deactivation.
Valérie Faivre, Anne Claire Lukaszewicz, Arnaud Alves, Dominique Charron, Didier Payen, Alain Haziot   +5 more
doaj   +1 more source

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

PLoS ONE, 2017
Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission.
Silmara R Sousa, Joshua S Wingerd, Andreas Brust, Christopher Bladen, Lotten Ragnarsson, Volker Herzig, Jennifer R Deuis, Sebastien Dutertre, Irina Vetter, Gerald W Zamponi, Glenn F King, Paul F Alewood, Richard J Lewis   +12 more
doaj   +1 more source

CD1a autoreactivity: When size does matter [PDF]

Journal of Experimental Medicine, 2021
CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but ...
openaire   +2 more sources

CD1a selectively captures endogenous cellular lipids that broadly block T cell response [PDF]

, 2021
We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM)
Willis, Richard, Dennis P. Orgill, dI&I RA-I&I I&I, Bohdan Pomahac, Chen, Yi-Ling, Talbot, Simon G, Sub IRAS Tox MTX Milieutoxicologie), Jérôme Le Nours, D. Branch Moody, Rachael A. Clark, Clark, Rachael A, Le Nours, Jérôme, Gurdyal S. Besra, Cheng, Tan-Yun, Immunologie, Richard Willis, Moody, D Branch, de Jong, Annemieke, Van Rhijn, Ildiko, Simon G. Talbot, Annemieke de Jong, Yi-Ling Chen, Wegrecki, Marcin, Tan-Yun Cheng, Natacha Veerapen, Jamie Rossjohn, Veerapen, Natacha, Graham Ogg, Ildiko Van Rhijn, Besra, Gurdyal S; id_orcid, Pomahac, Bohdan, Orgill, Dennis P, Cotton, Rachel N, Altman, John D, Rossjohn, Jamie, Marcin Wegrecki, John D. Altman, Rachel N. Cotton, Besra, Gurdyal S, Ogg, Graham   +39 more
core   +3 more sources

Human skin is colonized by T cells that recognize CD1a independently of lipid [PDF]

, 2021
CD1a-autoreactive T cells contribute to skin disease, but the identity of immunodominant self-lipid antigens and their mode of recognition are not yet solved. In most models, MHC and CD1 proteins serve as display platforms for smaller antigens.
Talbot, Simon G., Clark, Rachael A., Orgill, Dennis P., Wegrecki, Marcin, Willis, Richard A, Cotton, Rachel N., dI&I RA-I&I I&I, Moody, D. Branch, Talbot, Simon G, Pomahac, Bohdan, Altman, John D., Orgill, Dennis P, Clark, Rachael A, Le Nours, Jérôme, Cotton, Rachel N, Altman, John D, Cheng, Tan-Yun, Immunologie, Rossjohn, Jamie, Moody, D Branch, Willis, Richard A., de Jong, Annemieke, Ogg, Graham, Van Rhijn, Ildiko   +23 more
core   +2 more sources

Human CD1a Deficiency Is Common and Genetically Regulated [PDF]

The Journal of Immunology, 2013
Abstract CD1 proteins evolved to present diverse lipid Ags to T cells. In comparison with MHC proteins, CD1 proteins exhibit minimal allelic diversity as a result of nonsynonymous single nucleotide polymorphisms (SNPs). However, it is unknown if common SNPs in gene regulatory regions affect CD1 expression and function.
Chetan, Seshadri, Meera, Shenoy, Richard D, Wells, Tiffany, Hensley-McBain, Erica, Andersen-Nissen, M Juliana, McElrath, Tan-Yun, Cheng, D Branch, Moody, Thomas R, Hawn   +8 more
openaire   +2 more sources

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source

Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. [PDF]

PLoS ONE, 2016
Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non ...
Susanne M Reinartz, Joost van Tongeren, Danielle van Egmond, Esther J J de Groot, Wytske J Fokkens, Cornelis M van Drunen   +5 more
doaj   +1 more source