Results 41 to 50 of about 21,316 (223)

CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome. [PDF]

, 2008
AIMS: CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumour-derived glycolipid antigens to T cells and, consequently, the development of a successful ...
Bell, Cappello, Cappello, Coventry, Coventry, De Libero, Hillenbrand, Kichler-Lakomy, Kikuchi, Kohrt, La Rocca, Laguens, Pinzon-Charry, Poindexter, Treilleux   +14 more
core   +1 more source

Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

Journal of Pharmacy and Bioallied Sciences, 2014
Aim: The aim of this study is to identify and evaluate Langerhans cell (LC) in lichen planus (LP), lichenoid mucositis (LM) and normal mucosa (NM) using CD1a monoclonal antibody immunohistochemically.
M Devi, T R Saraswathi, K Ranganathan, D Vijayalakshmi, C Sreeja, S Shabana Fathima   +5 more
doaj   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. [PDF]

, 2015
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest ...
Casero, David, Crooks, Gay M, Ha, Vi Luan, Luong, Annie, Parekh, Chintan, Sandoval, Salemiz, Scholes, Jessica, Seet, Christopher S, Zhu, Yuhua   +8 more
core  

CD1a: a novel biomarker for Barrett's metaplasia? [PDF]

The Lancet Oncology, 2003
educational book. Alexandria: American Society for Clinical Oncology, 2001: 226–44. 49 Hussain M, Smith DC, Al-Sukhun S, et al. Preliminary results of HER-2/neu screening and treatment with trastuzumab (Herceptin) (T), paclitaxel (P), carboplatin (C) and gemcitabine (G) in patients with advanced urothelial cancer. Proc Am Soc Clin Oncol 2002; 21: 800a.
CAPPELLO, Francesco, RAPPA, Francesca, BUCCHIERI, Fabio, ZUMMO, Giovanni   +3 more
openaire   +3 more sources

Clinical and molecular characterization of early T-cell precursor leukemia : a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations [PDF]

, 2012
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome.
Neumann, Martin, Heesch, Sandra, Gökbuget, Nicola, Schwartz, Stefan, Schlee, Cornelia, Benlasfer, Ouidad, Farhadi-Sartangi, Nasrin, Thibaut, Julia, Burmeister, Thomas, Hoelzer, Dieter, Hofmann, Wolf-Karsten, Thiel, Eckhard, Baldus, Claudia   +12 more
core   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Origin Use of CD4, CD8, and CD1a Immunostains in Distinguishing Mycosis Fungoides from its Inflammatory Mimics: A Pilot Study

Indian Journal of Dermatology, 2012
Patch-stage/early mycosis fungoides (MF) is difficult to differentiate from benign dermatoses, despite several robust histologic criteria. Most studies include advanced lesions and data about early disease is limited.
Rajalakshmi Tirumalae, Poonam K Panjwani
doaj   +1 more source

CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma [PDF]

, 2015
CD1a is involved in presentation to the immune system of lipid antigen derived from tumor cells with subsequent T cell activation. Hsp60 is a molecular chaperone implicated in carcinogenesis by, for instance, modulating the immune reaction against the ...
CABIBI, Daniela, CAPPELLO, Francesco, Conway de Macario, E., INGRAO, Sabrina, Macario, A., PORCASI, Rossana, RAPPA, Francesca, Zucco, F.   +7 more
core   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source