Results 31 to 40 of about 14,609 (214)

Antigen-presentation of non-peptidic antigens lipid trafficking and loading [PDF]

, 2010
T cells recognize a broad variety of antigens, including peptides, lipids and non-peptidic phosphorylated metabolites. Clarification of the rules rendering non-peptidic molecules immunogenic is essential to understand and to influence the reactions of ...
Cavallari, Marco F.
core   +1 more source

62796 [PDF]

National Journal of Laboratory Medicine, 2023
Introduction: Psoriasis is a long-lasting autoimmune disease mediated by T-lymphocytes and dendritic cells. Langerhans cells are a unique population of dendritic cells found in the epidermis, where they can be identified by Cluster of Differentiation 1a (
Kavitha Yelavath, Ch Jyothi, T Divyagna, B Swapna Kumari   +3 more
doaj   +1 more source

CD1a autoreactivity: When size does matter [PDF]

Journal of Experimental Medicine, 2021
CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but ...
openaire   +2 more sources

CD1a selectively captures endogenous cellular lipids that broadly block T cell response [PDF]

, 2021
We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM)
Altman, JD, Willis, R, Besra, GS, Chen, YL, Rossjohn, J, Ogg, G, Pomahac, B, Clark, RA, Veerapen, N, Le Nours, J, Cotton, RN, Orgill, DP, Talbot, SG, Moody, DB, de Jong, A, Wegrecki, M, Cheng, TY, van Rhijn, I   +17 more
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Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis. [PDF]

PLoS ONE, 2012
BACKGROUND: Sepsis is a multifactorial pathology with high susceptibility to secondary infections. Innate and adaptive immunity are affected in sepsis, including monocyte deactivation.
Valérie Faivre, Anne Claire Lukaszewicz, Arnaud Alves, Dominique Charron, Didier Payen, Alain Haziot   +5 more
doaj   +1 more source

Human skin is colonized by T cells that recognize CD1a independently of lipid [PDF]

, 2021
CD1a-autoreactive T cells contribute to skin disease, but the identity of immunodominant self-lipid antigens and their mode of recognition are not yet solved. In most models, MHC and CD1 proteins serve as display platforms for smaller antigens.
Talbot, Simon G., Clark, Rachael A., Orgill, Dennis P., Wegrecki, Marcin, Willis, Richard A, Cotton, Rachel N., dI&I RA-I&I I&I, Moody, D. Branch, Talbot, Simon G, Pomahac, Bohdan, Altman, John D., Orgill, Dennis P, Clark, Rachael A, Le Nours, Jérôme, Cotton, Rachel N, Altman, John D, Cheng, Tan-Yun, Immunologie, Rossjohn, Jamie, Moody, D Branch, Willis, Richard A., de Jong, Annemieke, Ogg, Graham, Van Rhijn, Ildiko   +23 more
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Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors [PDF]

, 2022
CD1a is a monomorphic antigen-presenting molecule on dendritic cells that presents lipids to αβ T cells. Whether CD1a represents a ligand for other immune receptors remains unknown.
Ocampo, Tonatiuh A., von Borstel, Anouk, Wegrecki, Marcin, Gunasinghe, Sachith D., Le Nours, Jérôme, Cao, Thinh-Phat, Reijneveld, Josephine F., Gully, Benjamin S., Rossjohn, Jamie, Moody, D. Branch, Tin, Shin Yi, Van Rhijn, Ildiko   +11 more
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Human CD1a Deficiency Is Common and Genetically Regulated [PDF]

The Journal of Immunology, 2013
Abstract CD1 proteins evolved to present diverse lipid Ags to T cells. In comparison with MHC proteins, CD1 proteins exhibit minimal allelic diversity as a result of nonsynonymous single nucleotide polymorphisms (SNPs). However, it is unknown if common SNPs in gene regulatory regions affect CD1 expression and function.
Chetan, Seshadri, Meera, Shenoy, Richard D, Wells, Tiffany, Hensley-McBain, Erica, Andersen-Nissen, M Juliana, McElrath, Tan-Yun, Cheng, D Branch, Moody, Thomas R, Hawn   +8 more
openaire   +2 more sources

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

PLoS ONE, 2017
Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission.
Silmara R Sousa, Joshua S Wingerd, Andreas Brust, Christopher Bladen, Lotten Ragnarsson, Volker Herzig, Jennifer R Deuis, Sebastien Dutertre, Irina Vetter, Gerald W Zamponi, Glenn F King, Paul F Alewood, Richard J Lewis   +12 more
doaj   +1 more source

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source