Results 31 to 40 of about 15,640 (205)
CD1a function in human skin disease
Molecular Immunology, 2021 The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely ...
Annemieke de Jong, Graham Ogg
openaire +3 more sources
Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARγ [PDF]
Blood, 2006 AbstractAccumulating data have shown that the microenvironment of dendritic cells modulates subtype differentiation and CD1 expression, but the mechanisms by which exogenous factors confer these effects are poorly understood. Here we describe the dependence of CD1a− monocyte-derived dendritic cell (moDC) development on lipids associated with the ...
Peter, Gogolak +6 more
openaire +2 more sources
Monitoring Circulating CD207+CD1a+ Cells in Langerhans Cell Histiocytosis and Clinical Implications
, 2022 Langerhans cell histiocytosis (LCH) is a disorder characterized by an abnormal accumulation of CD207+ and CD1a+ cells in almost any tissue. Currently, there is a lack of prognostic markers to follow up patients and track disease reactivation or treatment
Nowak, Wanda +5 more
core +1 more source
Isolated Langerhans Histiocytosis in Thyroid: Thyroidectomy or Chemotherapy? [PDF]
Journal of Clinical and Diagnostic Research, 2015 Langerhans cell histiocytosis (LCH) is a rare disorder of mononuclear phagocytic system whose clinical presentation varies from the localised involvement of a single bone to a widely disseminated disease.
Anoop Attakkil +4 more
doaj +1 more source
Antigen-presentation of non-peptidic antigens lipid trafficking and loading [PDF]
, 2010 T cells recognize a broad variety of antigens, including peptides, lipids and non-peptidic phosphorylated metabolites. Clarification of the rules rendering non-peptidic molecules immunogenic is essential to understand and to influence the reactions of ...
Cavallari, Marco F.
core +1 more source
Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions. [PDF]
PLoS ONE, 2014 Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease.
Jennifer A West +8 more
doaj +1 more source
Functional CD1a is stabilized by exogenous lipids [PDF]
European Journal of Immunology, 2006 AbstractSelf‐glycosphingolipids bind to surface CD1 molecules and are readily displaced by other CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other antigen‐presenting molecules and its physiological importance is unclear.
Malanova, Vania +7 more
openaire +3 more sources
BMC Cancer, 2021 Background The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity.
Akimichi Minesaki +3 more
doaj +1 more source
National Journal of Laboratory Medicine, 2023 Introduction: Psoriasis is a long-lasting autoimmune disease mediated by T-lymphocytes and dendritic cells. Langerhans cells are a unique population of dendritic cells found in the epidermis, where they can be identified by Cluster of Differentiation 1a (
Kavitha Yelavath +3 more
doaj +1 more source
Capture and Molecular Control of CD1a-Autoreactive T Cells in Human Skin
, 2020 Functional studies of T cell response have revealed the existence of CD1a autoreactive T cells in human skin, and CD1a tetramers might directly enumerate T cells (TCRs) and dissect the molecular basis for activation.
Cotton, Rachel Nicole
core +4 more sources