Results 31 to 40 of about 21,316 (223)
Notch signaling during human T cell development [PDF]
, 2012 Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy +97 more
core +2 more sources
Pollen grains induce a rapid and biphasic eczematous immune response in atopic eczema patients [PDF]
, 2008 Introduction: Eczematous reactions to type I allergy-inducing antigens are documented in a subgroup of patients with atopic eczema. Yet, the underlying immunological mechanisms are not well understood.
Behrendt, Heidrun +7 more
core +2 more sources
CD1a autoreactive T cells recognize natural skin oils that function as headless antigens [PDF]
, 2014 CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids.
Altman, John D. +11 more
core +9 more sources
PLoS ONE, 2017 Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission.
Silmara R Sousa +12 more
doaj +1 more source
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. [PDF]
, 2012 Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset ...
Crooks, Gay M +7 more
core +1 more source
Biotechnology & Biotechnological Equipment, 2023 Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova +5 more
doaj +1 more source
Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels [PDF]
, 2001 Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions ...
Angénieux, C. +9 more
core +3 more sources
Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. [PDF]
PLoS ONE, 2016 Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non ...
Susanne M Reinartz +5 more
doaj +1 more source
A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter [PDF]
, 2017 Introduction: While most transcripts arising from the human T Cell Receptor locus reflect fully rearranged genes, several germline transcripts have been identified. We describe a new germline transcript arising from the human TCRB locus.
Abarrategui +33 more
core +2 more sources
Human CD1a Deficiency Is Common and Genetically Regulated [PDF]
The Journal of Immunology, 2013 Abstract CD1 proteins evolved to present diverse lipid Ags to T cells. In comparison with MHC proteins, CD1 proteins exhibit minimal allelic diversity as a result of nonsynonymous single nucleotide polymorphisms (SNPs). However, it is unknown if common SNPs in gene regulatory regions affect CD1 expression and function.
Chetan, Seshadri +8 more
openaire +2 more sources