Results 21 to 30 of about 14,609 (214)

CD1a function in human skin disease

Molecular Immunology, 2021
The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely ...
Annemieke de Jong, Graham Ogg
openaire   +3 more sources

Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a [PDF]

, 2023
Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a presents microbial ligands from bacteria colonizing the skin is unclear.
Karantza, Ioanna Maria, Uhlemann, Anne-Catrin, Chen, Yi-Ling, Moody, D. Branch, Tin, Shin Yi, Ng, Soo Weei, Cheng, Bin, Rohde, Christine H., Cheng, Tan-Yun, Monnot, Gwennaëlle C., Sallee, Brigitte N., Han, Arnold, de Jong, Annemieke, Wegrecki, Marcin, Shahine, Adam, Chakravarthy, Reka, Youssef, Soundos, Monga, Isha, Garcia-Vilas, Javier A., Bordone, Lindsey A., Rossjohn, Jamie, Uwakwe, Laura N., Tillman, Alice, Ogg, Graham, Khaleel, Alexandra E.   +24 more
core   +1 more source

Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARγ [PDF]

Blood, 2006
AbstractAccumulating data have shown that the microenvironment of dendritic cells modulates subtype differentiation and CD1 expression, but the mechanisms by which exogenous factors confer these effects are poorly understood. Here we describe the dependence of CD1a− monocyte-derived dendritic cell (moDC) development on lipids associated with the ...
Peter, Gogolak, Bence, Rethi, Istvan, Szatmari, Arpad, Lanyi, Balazs, Dezso, Laszlo, Nagy, Eva, Rajnavolgyi   +6 more
openaire   +2 more sources

Isolated Langerhans Histiocytosis in Thyroid: Thyroidectomy or Chemotherapy? [PDF]

Journal of Clinical and Diagnostic Research, 2015
Langerhans cell histiocytosis (LCH) is a rare disorder of mononuclear phagocytic system whose clinical presentation varies from the localised involvement of a single bone to a widely disseminated disease.
Anoop Attakkil, Vandana Thorawade, Mohan Jagade, Rajesh Kar, Kartik Parelkar   +4 more
doaj   +1 more source

Functional CD1a is stabilized by exogenous lipids [PDF]

European Journal of Immunology, 2006
AbstractSelf‐glycosphingolipids bind to surface CD1 molecules and are readily displaced by other CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other antigen‐presenting molecules and its physiological importance is unclear.
Manolova V, Kistowska M, Paoletti S, Baltariu GM, Bausinger H, Hanau D, Mori L, De Libero G   +7 more
openaire   +3 more sources

Monitoring Circulating CD207+CD1a+ Cells in Langerhans Cell Histiocytosis and Clinical Implications

, 2022
Langerhans cell histiocytosis (LCH) is a disorder characterized by an abnormal accumulation of CD207+ and CD1a+ cells in almost any tissue. Currently, there is a lack of prognostic markers to follow up patients and track disease reactivation or treatment
Nowak, Wanda, Carrera Silva, Eugenio Antonio, Fortunati, Daniela, Rosso, Diego, Olexen, Cinthia Mariel, Errasti, Andrea Emilse   +5 more
core   +1 more source

Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions. [PDF]

PLoS ONE, 2014
Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease.
Jennifer A West, Sharon L Olsen, Jenée M Mitchell, Ross E Priddle, Jennifer M Luke, Selma Olsson Akefeldt, Jan-Inge Henter, Christopher Turville, George Kannourakis   +8 more
doaj   +1 more source

CD1a Reactivity in Non-neoplastic Adenohypophysis [PDF]

American Journal of Surgical Pathology, 2016
Within the differential diagnosis of patients presenting with sellar or suprasellar lesions is Langerhans cell histiocytosis (LCH). CD1a staining is frequently used to identify the presence of an abnormal proliferation of Langerhans cells on histologic sections and contributes to the diagnosis of LCH.
David J, Pisapia, Marc K, Rosenblum, Ehud, Lavi   +2 more
openaire   +2 more sources

Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy

BMC Cancer, 2021
Background The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity.
Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi, Shinichi Aishima   +3 more
doaj   +1 more source

A polymorphism in human CD1A is associated with susceptibility to tuberculosis [PDF]

Genes & Immunity, 2014
CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease.
Seshadri, C, Thuong, NTT, Yen, NTB, Bang, ND, Chau, TTH, Thwaites, GE, Dunstan, SJ, Hawn, TR   +7 more
openaire   +5 more sources