The S100 protein family in bladder cancer: mechanisms, clinical value, and targeted therapeutic prospects [PDF]
Frontiers in OncologyBackgroundBladder cancer (BC) is a highly heterogeneous malignancy with limited molecular biomarkers and therapeutic targets. The S100 protein family, a group of calcium-binding proteins, has emerged as a crucial regulator in cancer development. However,
Lihao Zhang +7 more
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S100 Protein Family in Lung Cancer: an Updated Narrative Review [PDF]
Cancer Management and ResearchTing Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No.
Wang T, Liu R
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Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma [PDF]
Frontiers in Genetics, 2021 S100 protein family members (S100s) are commonly dysregulated in various tumors including hepatocellular carcinoma (HCC). However, the diverse expression, mutation, prognosis and associations with immune infiltration of S100s in HCC have yet to be ...
Susu Zheng +12 more
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Multifunctional Role of S100 Protein Family in the Immune System: An Update [PDF]
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
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The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases [PDF]
Pulmonary Medicine, 2021 The S100 protein family consists of over 20 members in humans that are involved in many intracellular and extracellular processes, including proliferation, differentiation, apoptosis, Ca2+ homeostasis, energy metabolism, inflammation, tissue repair, and ...
Zeeshan Sattar +4 more
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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay [PDF]
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
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Role of the S100 protein family in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2022 Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma).
Yuan-yuan Wu +6 more
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Advances in S100 protein family for gynecological malignancies [PDF]
Discover OncologyThe S100 protein family comprises more than 20 structurally related members with diverse functions. These proteins regulate cellular responses by acting both as intracellular Ca2+ binding receptors and extracellular factors.
Shenglong Wu, Junfen Xu
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Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS ONE, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Lucas C Wheeler +3 more
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The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
Discover OncologyBackground The S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological processes, including promotion of growth, metastasis and immune evasion of tumor.
Xiaojie Liang +9 more
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