Results 1 to 10 of about 29,623 (214)
The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases [PDF]
Pulmonary Medicine, 2021 The S100 protein family consists of over 20 members in humans that are involved in many intracellular and extracellular processes, including proliferation, differentiation, apoptosis, Ca2+ homeostasis, energy metabolism, inflammation, tissue repair, and ...
Zeeshan Sattar +4 more
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Multifunctional Role of S100 Protein Family in the Immune System: An Update [PDF]
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
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Advances in S100 protein family for gynecological malignancies [PDF]
Discover OncologyThe S100 protein family comprises more than 20 structurally related members with diverse functions. These proteins regulate cellular responses by acting both as intracellular Ca2+ binding receptors and extracellular factors.
Shenglong Wu, Junfen Xu
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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay [PDF]
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
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Role of the S100 protein family in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2022 Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma).
Yuan-yuan Wu +6 more
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Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma [PDF]
Frontiers in Genetics, 2021 S100 protein family members (S100s) are commonly dysregulated in various tumors including hepatocellular carcinoma (HCC). However, the diverse expression, mutation, prognosis and associations with immune infiltration of S100s in HCC have yet to be ...
Susu Zheng +12 more
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S100 Protein Family in Lung Cancer: an Updated Narrative Review [PDF]
Cancer Management and ResearchTing Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No.
Wang T, Liu R
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The Role of the S100 Protein Family in Glioma. [PDF]
J Cancer, 2022 The S100 protein family consists of 25 members and share a common structure defined in part by the Ca2+ binding EF-hand motif. Multiple members' dysregulated expression is associated with progression, diagnosis and prognosis in a broad range of diseases, especially in tumors.
Wang H, Mao X, Ye L, Cheng H, Dai X.
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Frontiers in Cell and Developmental Biology, 2021 Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to the development of novel treatment strategies.
Minxia Liu +16 more
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The S100 protein family in bladder cancer: mechanisms, clinical value, and targeted therapeutic prospects [PDF]
Frontiers in OncologyBackgroundBladder cancer (BC) is a highly heterogeneous malignancy with limited molecular biomarkers and therapeutic targets. The S100 protein family, a group of calcium-binding proteins, has emerged as a crucial regulator in cancer development. However,
Lihao Zhang +7 more
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