Results 31 to 40 of about 29,623 (214)

Interaction of S100A6 Protein with the Four-Helical Cytokines

Biomolecules, 2023
S100 is a family of over 20 structurally homologous, but functionally diverse regulatory (calcium/zinc)-binding proteins of vertebrates. The involvement of S100 proteins in numerous vital (patho)physiological processes is mediated by their interaction ...
Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov   +8 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

Frontiers in Oncology, 2021
Pancreatic cancer (PC) is a highly malignant tumor occurring in the digestive system. Currently, there is a lack of specific and effective interventions for PC; thus, further exploration regarding the pathogenesis of this malignancy is warranted.
Yu Wu, Yu Wu, Qi Zhou, Qi Zhou, Fangyue Guo, Fangyue Guo, Mingming Chen, Mingming Chen, Xufeng Tao, Deshi Dong   +9 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Significance of Elecsys (R) S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients [PDF]

, 2006
Background: The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from ...
Kirchhoff, Chlodwig, Gippner-Steppert, Cornelia, Mussack, Thomas, Buhmann, Sonja, Jochum, Marianne, Ladurner, Roland, Biberthaler, Peter, Mutschler, Wolf   +7 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]

, 2009
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K., Helmut Wittkowski, Anatoli Ianoul, Igor B Bronstein, Shekhtman, Alexander, Bjoerk, Per, Alexander Shekhtman, Per Bjoerk, Foell, Dirk, Wei He, Igor K Lednev, Olga V Moroz, He, Wei, Burkitt, William I., Xie, Jingjing, Derrick, Peter J., Bronstein, Igor B., Vera Novitskaya, Polyakova, Oxana, Ianoul, Anatoli, Dirk Foell, Will Burkitt, Oxana Polyakova, Moroz, Olga V., Peter J Derrick, Wittkowski, Helmut, Novitskaya, Vera, Jingjing Xie   +27 more
core   +1 more source

Dissecting novel regulatory mechanisms of S100A1 on cardiac function [PDF]

, 2007
6.1 Extracellular S100A1 inhibits apoptosis in ventricular cardiomyocytes: via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) Growing evidence indicates that members of the S100 protein family exert intracellular but ...
Börries, Melanie
core   +1 more source

A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions. [PDF]

J Pathol Clin Res
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Yeung MC, Saoud C, Chiang S, Hameed M, Antonescu CR.   +4 more
europepmc   +2 more sources

Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)

Molecules, 2021
S100B, a biomarker of malignant melanoma, interacts with the p53 protein and diminishes its tumor suppressor function, which makes this S100 family member a promising therapeutic target for treating malignant melanoma.
Brianna D. Young, Wenbo Yu, Darex J. Vera Rodríguez, Kristen M. Varney, Alexander D. MacKerell, David J. Weber   +5 more
doaj   +1 more source