Results 11 to 20 of about 29,623 (214)
A multiomics analysis of S100 protein family in breast cancer. [PDF]
Oncotarget, 2018 The S100 gene family is the largest subfamily of calcium binding proteins of EF-hand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators. There is a growing interest in the S100 proteins and their relationships with different cancers because of their involvement in a variety of ...
Cancemi P +6 more
europepmc +8 more sources
Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS ONE, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Lucas C Wheeler +3 more
doaj +4 more sources
Nucleotide homologies in genes encoding members of the S100 protein family
Biochimica Et Biophysica Acta - Molecular Cell Research, 1996 Members of the S100 protein family exhibit a unique pattern of cell/tissue-specific expression and approx. 50% similarity at the amino-acid level. The cDNAs encoding many of these proteins from a variety of species are now available making a comparison of these family members at the nucleotide level possible.
Danna B Zimmer
exaly +4 more sources
S100 Protein Family in Rheumatological Diseases [PDF]
Gazi Medical Journal, 2022 Inflammation in joint tissues is one of the causes of early mortality in rheumatological diseases. In fact, inflammation process is followed by cell infiltration, synovial tissue proliferation, cartilage and bone destruction. Therefore, various studies have been done to understand the pathogenesis and biochemical mechanisms of inflammation ...
Dumur, Seyma +4 more
core +5 more sources
Probing the S100 protein family through genomic and functional analysis
Genomics, 2004 The EF-hand superfamily of calcium binding proteins includes the S100, calcium binding protein, and troponin subfamilies. This study represents a genome, structure, and expression analysis of the S100 protein family, in mouse, human, and rat. We confirm the high level of conservation between mammalian sequences but show that four members, including ...
Ravasi, Timothy +9 more
openaire +6 more sources
The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
Discover OncologyBackground The S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological processes, including promotion of growth, metastasis and immune evasion of tumor.
Xiaojie Liang +9 more
doaj +2 more sources
S100 Proteins in Acute Myeloid Leukemia [PDF]
Neoplasia: An International Journal for Oncology Research, 2018 The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell proliferation, cell differentiation, regulation of transcription factors, inflammation, chemotaxis,
Annette K. Brenner, Øystein Bruserud
doaj +2 more sources
Calcium-dependent and -independent interactions of the S100 protein family [PDF]
Biochemical Journal, 2006 The S100 proteins comprise at least 25 members, forming the largest group of EF-hand signalling proteins in humans. Although the proteins are expressed in many tissues, each S100 protein has generally been shown to have a preference for expression in one particular tissue or cell type.
Gary S Shaw, Shaw Gary S
exaly +3 more sources
S100 protein family in human cancer. [PDF]
Am J Cancer Res, 2014 S100 protein family has been implicated in multiple stages of tumorigenesis and progression. Among the S100 genes, 22 are clustered at chromosome locus 1q21, a region frequently rearranged in cancers. S100 protein possesses a wide range of intracellular and extracellular functions such as regulation of calcium homeostasis, cell proliferation, apoptosis,
Chen H, Xu C, Jin Q, Liu Z.
europepmc +2 more sources
S100 Protein Family and Tumorigenesis [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Deep insight on S100 Protein Family and ...
G Srikrishna, HH Freeze
openaire +2 more sources