Results 11 to 20 of about 30,146 (155)

Proteomic profiling of pulpal and periapical diseases: a systematic review [PDF]

Frontiers in Dental Medicine
Pulpal and periapical diseases represent a significant burden in endodontic practice, yet their molecular pathogenesis remains incompletely understood.
Ameesha S. Rai, Aaron M. Iype, Raksha Bhat, Preethesh Shetty   +3 more
doaj   +2 more sources

S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma

Frontiers in Cell and Developmental Biology, 2021
Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to the development of novel treatment strategies.
Minxia Liu, Yinyin Wang, Juho J. Miettinen, Romika Kumari, Muntasir Mamun Majumder, Ciara Tierney, Ciara Tierney, Despina Bazou, Alun Parsons, Minna Suvela, Juha Lievonen, Raija Silvennoinen, Pekka Anttila, Paul Dowling, Peter O’Gorman, Jing Tang, Caroline A. Heckman   +16 more
doaj   +1 more source

Influence of S100A2 in Human Diseases

Diagnostics, 2022
S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain.
Hitomi Sugino, Yu Sawada
doaj   +1 more source

The Calcium Binding Protein S100A11 and Its Roles in Diseases

Frontiers in Cell and Developmental Biology, 2021
The calcium binding protein S100 family in humans contains 21 known members, with each possessing a molecular weight between 10 and 14 kDa. These proteins are characterized by a unique helix-loop-helix EF hand motif, and often form dimers and multimers ...
Linqiang Zhang, Linqiang Zhang, Tingting Zhu, Huilai Miao, Huilai Miao, Bin Liang, Bin Liang, Bin Liang   +7 more
doaj   +1 more source

S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors

Biomolecules, 2023
Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis.
Angelo Mandarino, Swetha Thiyagarajan, Allana C. F. Martins, Roberto da Silva Gomes, Stefan W. Vetter, Estelle Leclerc   +5 more
doaj   +1 more source

Blocking the interaction between S100A9 protein and RAGE V domain using S100A12 protein. [PDF]

PLoS ONE, 2018
The proteins S100A9 and S100A12 are associated with the human S100 calcium-binding protein family. These proteins promote interaction with target proteins and alter their conformation when they bind to calcium ions in EF-hand motifs. The V domain of RAGE
Revansiddha Katte, Chin Yu
doaj   +1 more source

Interaction of S100A6 Protein with the Four-Helical Cytokines

Biomolecules, 2023
S100 is a family of over 20 structurally homologous, but functionally diverse regulatory (calcium/zinc)-binding proteins of vertebrates. The involvement of S100 proteins in numerous vital (patho)physiological processes is mediated by their interaction ...
Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov   +8 more
doaj   +1 more source

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

Frontiers in Oncology, 2021
Pancreatic cancer (PC) is a highly malignant tumor occurring in the digestive system. Currently, there is a lack of specific and effective interventions for PC; thus, further exploration regarding the pathogenesis of this malignancy is warranted.
Yu Wu, Yu Wu, Qi Zhou, Qi Zhou, Fangyue Guo, Fangyue Guo, Mingming Chen, Mingming Chen, Xufeng Tao, Deshi Dong   +9 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source