Advances in S100 protein family for gynecological malignancies [PDF]
Discover OncologyThe S100 protein family comprises more than 20 structurally related members with diverse functions. These proteins regulate cellular responses by acting both as intracellular Ca2+ binding receptors and extracellular factors.
Shenglong Wu, Junfen Xu
doaj +3 more sources
Promiscuity mapping of the S100 protein family using a high-throughput holdup assay [PDF]
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
doaj +2 more sources
Multifunctional Role of S100 Protein Family in the Immune System: An Update [PDF]
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
doaj +2 more sources
The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases [PDF]
Pulmonary Medicine, 2021 The S100 protein family consists of over 20 members in humans that are involved in many intracellular and extracellular processes, including proliferation, differentiation, apoptosis, Ca2+ homeostasis, energy metabolism, inflammation, tissue repair, and ...
Zeeshan Sattar +4 more
doaj +2 more sources
Susceptibility-Weighted MRI for Predicting NF-2 Mutations and S100 Protein Expression in Meningiomas [PDF]
DiagnosticsS100 protein expression levels and neurofibromatosis type 2 (NF-2) mutations result in different disease courses in meningiomas. This study aimed to investigate non-invasive biomarkers of NF-2 copy number loss and S100 protein expression in meningiomas ...
Sena Azamat +10 more
doaj +2 more sources
Role of the S100 protein family in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2022 Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma).
Yuan-yuan Wu +6 more
doaj +2 more sources
Value of NSE and S100 Protein of Kawasaki Disease with aseptic meningitis in Infant [PDF]
Open Life Sciences, 2019 The cerebrospinal fluid content was examined for concentrations of S100 protein and neuron-specific enolase (NSE) in two diseases, Kawasaki disease (KD) with aseptic meningitis (1-3 months) and purulent meningitis (PM), to determine whether or not these ...
Wang Jiangtao +6 more
doaj +2 more sources
S100 Protein Family in Lung Cancer: an Updated Narrative Review [PDF]
Cancer Management and ResearchTing Wang, Rui Liu Department of Respiratory Medicine, Xi’an People’s Hospital (Xi’an No.4 hospital), Xi’an, 710004, People’s Republic of ChinaCorrespondence: Rui Liu, Department of Respiratory, Xi’an People’s Hospital (Xi’an No.4 hospital), No.
Wang T, Liu R
doaj +2 more sources
The S100 protein family in bladder cancer: mechanisms, clinical value, and targeted therapeutic prospects [PDF]
Frontiers in OncologyBackgroundBladder cancer (BC) is a highly heterogeneous malignancy with limited molecular biomarkers and therapeutic targets. The S100 protein family, a group of calcium-binding proteins, has emerged as a crucial regulator in cancer development. However,
Lihao Zhang +7 more
doaj +2 more sources
S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis [PDF]
BiomoleculesAtherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, immune cells, and fibrotic tissue within the arterial wall.
Atreya J. Kulkarni, Vikrant Rai
doaj +2 more sources