The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases [PDF]
Pulmonary Medicine, 2021 The S100 protein family consists of over 20 members in humans that are involved in many intracellular and extracellular processes, including proliferation, differentiation, apoptosis, Ca2+ homeostasis, energy metabolism, inflammation, tissue repair, and ...
Zeeshan Sattar +4 more
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Multifunctional Role of S100 Protein Family in the Immune System: An Update [PDF]
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
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Role of the S100 protein family in rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2022 Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma).
Yuan-yuan Wu +6 more
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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay [PDF]
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
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A multiomics analysis of S100 protein family in breast cancer. [PDF]
Oncotarget, 2018 The S100 gene family is the largest subfamily of calcium binding proteins of EFhand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators.
Cancemi P +6 more
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Advances in S100 protein family for gynecological malignancies [PDF]
Discover OncologyThe S100 protein family comprises more than 20 structurally related members with diverse functions. These proteins regulate cellular responses by acting both as intracellular Ca2+ binding receptors and extracellular factors.
Shenglong Wu, Junfen Xu
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Susceptibility-Weighted MRI for Predicting NF-2 Mutations and S100 Protein Expression in Meningiomas [PDF]
DiagnosticsS100 protein expression levels and neurofibromatosis type 2 (NF-2) mutations result in different disease courses in meningiomas. This study aimed to investigate non-invasive biomarkers of NF-2 copy number loss and S100 protein expression in meningiomas ...
Sena Azamat +10 more
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The Role of the S100 Protein Family in Glioma. [PDF]
J Cancer, 2022 The S100 protein family consists of 25 members and share a common structure defined in part by the Ca2+ binding EF-hand motif. Multiple members' dysregulated expression is associated with progression, diagnosis and prognosis in a broad range of diseases,
Wang H, Mao X, Ye L, Cheng H, Dai X.
europepmc +2 more sources
Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS One, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Wheeler LC +3 more
europepmc +2 more sources
Assessment of S100 protein expression in the epididymis of juvenile and adult European bison.
Folia Histochemica et Cytobiologica, 2010 In our study, we decided to compare S100 protein expression in the material obtained from the epididymes of 5- and 12-month-old calves, and adult European bison, and to detect any differences in S100 expression according to the animal age and size of the
Joanna Surdyk-Zasada +4 more
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