Results 21 to 30 of about 3,415,247 (147)

S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis [PDF]

Biomolecules
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, immune cells, and fibrotic tissue within the arterial wall.
Atreya J. Kulkarni, Vikrant Rai
doaj   +2 more sources

Fractal Aspects of Human S100 Protein Structures

Applied Sciences
This study analyzes the fractal aspects of the structures of S100 proteins to better understand their structural complexity. We take into account 33 solution structures and 18 crystal structures corresponding to human S100 proteins for the calculation of
David Emanuel Petreuș, Adriana Isvoran
doaj   +2 more sources

S100 as Serum Tumor Marker in Advanced Uveal Melanoma

Biomolecules, 2023
S100 protein is routinely used as a serum tumor marker in advanced cutaneous melanoma. However, there is scarce and inconclusive evidence on its value in monitoring disease progression of uveal melanoma.
Martin Salzmann, Alexander H. Enk, Jessica C. Hassel   +2 more
doaj   +1 more source

Localisation of S100 Protein and Acetylated Tubulin in Sheep Pancreas

Folia Veterinaria, 2021
The pancreas plays a critical role in the control of nutritional homeostasis. It consists of two major parts, the exocrine pancreas, and the endocrine pancreas.
Marettová E., Maretta M.
doaj   +1 more source

S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors

Biomolecules, 2023
Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis.
Angelo Mandarino, Swetha Thiyagarajan, Allana C. F. Martins, Roberto da Silva Gomes, Stefan W. Vetter, Estelle Leclerc   +5 more
doaj   +1 more source

Membrane interactions of S100A12 (Calgranulin C) [PDF]

, 2013
S100A12 (Calgranulin C) is a small acidic calcium-binding peripheral membrane protein with two EF-hand structural motifs. It is expressed in macrophages and lymphocytes and highly up-regulated in several human inflammatory diseases.
Costa-Filho, A.J., Wallace, Bonnie A., Araujo, A.P.U., Hofmann, A., Garcia, A.F., Lopes, J.L.S.   +5 more
core   +3 more sources

S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis. [PDF]

PLoS ONE, 2012
Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our laboratory ...
Xiaoxuan Ning, Shiren Sun, Kun Zhang, Jie Liang, Yucai Chuai, Yuan Li, Xiaoming Wang   +6 more
doaj   +1 more source

S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma

Frontiers in Cell and Developmental Biology, 2021
Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to the development of novel treatment strategies.
Minxia Liu, Yinyin Wang, Juho J. Miettinen, Romika Kumari, Muntasir Mamun Majumder, Ciara Tierney, Ciara Tierney, Despina Bazou, Alun Parsons, Minna Suvela, Juha Lievonen, Raija Silvennoinen, Pekka Anttila, Paul Dowling, Peter O’Gorman, Jing Tang, Caroline A. Heckman   +16 more
doaj   +1 more source

Significance of Elecsys (R) S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients [PDF]

, 2006
Background: The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from ...
Kirchhoff, Chlodwig, Gippner-Steppert, Cornelia, Mussack, Thomas, Buhmann, Sonja, Jochum, Marianne, Ladurner, Roland, Biberthaler, Peter, Mutschler, Wolf   +7 more
core   +1 more source

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]

, 2009
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K., Helmut Wittkowski, Anatoli Ianoul, Igor B Bronstein, Shekhtman, Alexander, Bjoerk, Per, Alexander Shekhtman, Per Bjoerk, Foell, Dirk, Wei He, Igor K Lednev, Olga V Moroz, He, Wei, Burkitt, William I., Xie, Jingjing, Derrick, Peter J., Bronstein, Igor B., Vera Novitskaya, Polyakova, Oxana, Ianoul, Anatoli, Dirk Foell, Will Burkitt, Oxana Polyakova, Moroz, Olga V., Peter J Derrick, Wittkowski, Helmut, Novitskaya, Vera, Jingjing Xie   +27 more
core   +1 more source