Results 41 to 50 of about 29,623 (214)
Large-scale proteomic identification of S100 proteins in breast cancer tissues
BMC Cancer, 2010 Background Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices.
Cancemi Patrizia +8 more
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S100 proteins in cardiovascular diseases
Molecular Medicine, 2023 Cardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts.
Yue Zhou +5 more
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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor [PDF]
Proceedings of the National Academy of Sciences, 2005 S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease and Down's syndrome. S100A4 is correlated with the development of metastasis. Both proteins bind to p53 tumor suppressor. We found that both S100B and S100A4 bind to the tetramerization domain of p53 (residues 325-355) only when exposed in lower oligomerization
Fernández-Fernández, María Rosario +2 more
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BMC Cancer, 2008 Background The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation ...
Zheng Jian-Yong +8 more
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Recent Advances in Molecular and Cellular Functions of S100A10
Biomolecules, 2023 S100A10 (p11, annexin II light chain, calpactin light chain) is a multifunctional protein with a wide range of physiological activity. S100A10 is unique among the S100 family members of proteins since it does not bind to Ca2+, despite its sequence and ...
Gillian C. Okura +2 more
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Open Medicine, 2020 S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC).
Song Dongqiang +4 more
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Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]
, 2005 Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
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Identification of new biomarkers of hepatic cancer stem cells through proteomic profiling [PDF]
Journal of Liver CancerBackgrounds/Aims In hepatocellular carcinoma (HCC), which exhibits high mortality and recurrence rates globally, the traits of cancer stem cells (CSCs) that significantly influence recurrence and metastasis are not well understood. CSCs are self-renewing
Sung Hoon Choi +7 more
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Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins. [PDF]
PLoS ONE, 2013 S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins.
Sofia B Carvalho +5 more
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Membrane interactions of S100A12 (Calgranulin C)
, 2013 S100A12 (Calgranulin C) is a small acidic calcium-binding peripheral membrane protein with two EF-hand structural motifs. It is expressed in macrophages and lymphocytes and highly up-regulated in several human inflammatory diseases.
Costa-Filho, A.J. +5 more
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