Results 61 to 70 of about 29,623 (214)

Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. [PDF]

PLoS ONE, 2009
Genes of the S100 fused-type protein (SFTP) family are clustered within the epidermal differentiation complex and encode essential components that maintain epithelial homeostasis and barrier functions.
Zhihong Wu, Britta Hansmann, Ulf Meyer-Hoffert, Regine Gläser, Jens-Michael Schröder   +4 more
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Structural and functional diversification in the teleost S100 family of calcium-binding proteins [PDF]

BMC Evolutionary Biology, 2008
Abstract Background Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling. The evolutionary origin of this family is still uncertain and most studies have examined mammalian family members.
Korsching Sigrun I, Saraiva Luis R, Kraemer Andreas M   +2 more
openaire   +3 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Role of S100 proteins in health and disease [PDF]

, 2020
The S100 family of proteins contains 25 known members that share a high degree of sequence and structural similarity. However, only a limited number of family members have been characterized in depth, and the roles of other members are likely undervalued.
Garrie, K, Turner, MD, Gonzalez, LL
core   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Structural Heterogeneity and Bioimaging of S100 Amyloid Assemblies

, 2014
S100 proteins are small EF-hand Ca2+-binding proteins involved in diverse cellular processes such as cell survival, proliferation and differentiation. Many S100 proteins also bind additional metal ions which modulate their folding and activity.
Gomes, Cláudio M.,, Cardoso, Isabel,, Fritz, Günter,, Hugo M. Botelho, Carvalho, Sofia B.,, Yanamandra, Kiran,, Sofia B. Carvalho, Morozova-Roche, Ludmilla,, Cláudio M. Gomes, Botelho, Hugo M.,, Günter Fritz, Ludmilla A. Morozova-Roche, Isabel Cardoso, Kiran Yanamandra   +13 more
core   +1 more source

Label-free Selected Reaction Monitoring Enables Multiplexed Quantitation of S100 Protein Isoforms in Cancer Cells

, 2016
In humans, the S100 protein family is composed of 21 highly related low molecular weight (∼10 kDa) proteins. These proteins are known to have diagnostic, prognostic, and predictive value in a variety of cancers, but their small size and high sequence ...
Juan Martínez-Aguilar (1930681), Mark P. Molloy (607281)   +1 more
core   +3 more sources

Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells

Scientific Reports, 2017
Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured.
Juha Piltti, Joakim Bygdell, Cecilia Fernández-Echevarría, Daniel Marcellino, Mikko J. Lammi   +4 more
doaj   +1 more source

Downregulation of S100 calcium binding protein A12 inhibits the growth of glioma cells

BMC Cancer, 2020
Background S100 calcium binding protein A12 (S100A12) is a member of the S100 protein family and is widely expressed in neutrophil and low expressed in lymphocytes and monocyte. However, the role of S100A12 in glioma has not yet been identified.
Chunhe Lu, Jia Liu, Mingze Yao, Lun Li, Guangyu Li   +4 more
doaj   +1 more source