Results 21 to 30 of about 29,623 (214)
Erythropoietin Interacts with Specific S100 Proteins
Biomolecules, 2022 Erythropoietin (EPO) is a clinically significant four-helical cytokine, exhibiting erythropoietic, cytoprotective, immunomodulatory, and cancer-promoting activities.
Alexey S. Kazakov +8 more
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S100 proteins as a key immunoregulatory mechanism for NLRP3 inflammasome [PDF]
Frontiers in ImmunologyThe S100 superfamily of proteins consists of Ca2+-binding proteins characterized by the EF-hand motif. Certain members of this protein family, such as S100A8, S100A9, and S100A12, have been effectively utilized as biomarkers for the detection and ...
Shahinur Acter, Qing Lin
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Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis [PDF]
Nature CommunicationsProgressive multiple sclerosis (PMS) is an autoimmune demyelinating disease of the central nervous system (CNS) in humans. PMS is defined by neuroinflammation and axonal damage with advancing neurological disabilities, although the underlying molecular ...
Henry Wang +11 more
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S100 Proteins As an Important Regulator of Macrophage Inflammation
Frontiers in Immunology, 2018 The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and ...
Chang Xia +5 more
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Chromosomal mapping, differential origin and evolution of the
Genetics Selection Evolution, 2008 S100 proteins are calcium-binding proteins, which exist only in vertebrates and which constitute a large protein family. The origin and evolution of the S100 family in vertebrate lineages remain a challenge.
Zhou Rongjia, Cheng Hanhua, Shang Xuan
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Influence of S100A2 in Human Diseases
Diagnostics, 2022 S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain.
Hitomi Sugino, Yu Sawada
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The Calcium Binding Protein S100A11 and Its Roles in Diseases
Frontiers in Cell and Developmental Biology, 2021 The calcium binding protein S100 family in humans contains 21 known members, with each possessing a molecular weight between 10 and 14 kDa. These proteins are characterized by a unique helix-loop-helix EF hand motif, and often form dimers and multimers ...
Linqiang Zhang +7 more
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Ca2+- binding proteins of the S100 family in preeclampsia
Placenta, 2022 S100 proteins bind Ca2+ and regulate various signaling pathways inside and outside the cell. They are expressed in vertebrates and exhibit tissue and cell specific distribution. Of note, increased level of S100 proteins is observed in different pathologies such as cancers, nervous system diseases/neurodegeneration, inflammation or cardiovascular ...
Ewelina Jurewicz, Anna Filipek
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S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors
Biomolecules, 2023 Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis.
Angelo Mandarino +5 more
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Blocking the interaction between S100A9 protein and RAGE V domain using S100A12 protein. [PDF]
PLoS ONE, 2018 The proteins S100A9 and S100A12 are associated with the human S100 calcium-binding protein family. These proteins promote interaction with target proteins and alter their conformation when they bind to calcium ions in EF-hand motifs. The V domain of RAGE
Revansiddha Katte, Chin Yu
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