Results 21 to 30 of about 30,146 (155)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

S100 Proteins in Acute Myeloid Leukemia

Neoplasia: An International Journal for Oncology Research, 2018
The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell proliferation, cell differentiation, regulation of transcription factors, inflammation, chemotaxis,
Annette K. Brenner, Øystein Bruserud
doaj   +1 more source

Erythropoietin Interacts with Specific S100 Proteins

Biomolecules, 2022
Erythropoietin (EPO) is a clinically significant four-helical cytokine, exhibiting erythropoietic, cytoprotective, immunomodulatory, and cancer-promoting activities.
Alexey S. Kazakov, Evgenia I. Deryusheva, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov   +8 more
doaj   +1 more source

Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)

Molecules, 2021
S100B, a biomarker of malignant melanoma, interacts with the p53 protein and diminishes its tumor suppressor function, which makes this S100 family member a promising therapeutic target for treating malignant melanoma.
Brianna D. Young, Wenbo Yu, Darex J. Vera Rodríguez, Kristen M. Varney, Alexander D. MacKerell, David J. Weber   +5 more
doaj   +1 more source

Large-scale proteomic identification of S100 proteins in breast cancer tissues

BMC Cancer, 2010
Background Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices.
Cancemi Patrizia, Di Cara Gianluca, Albanese Nadia, Costantini Francesca, Marabeti Maria, Musso Rosa, Lupo Carmelo, Roz Elena, Pucci-Minafra Ida   +8 more
doaj   +1 more source

S100 proteins in cardiovascular diseases

Molecular Medicine, 2023
Cardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts.
Yue Zhou, Yiwen Zha, Yongqi Yang, Tan Ma, Hongliang Li, Jingyan Liang   +5 more
doaj   +1 more source

In silico analysis and verification of S100 gene expression in gastric cancer

BMC Cancer, 2008
Background The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation ...
Zheng Jian-Yong, Du Jian-Jun, Chen Dong-Li, Zhang Hong-Wei, Dong Guang-Long, Li Xue, Liu Ji, Li Ji-Peng, Wang Wei-Zhong   +8 more
doaj   +1 more source

Recent Advances in Molecular and Cellular Functions of S100A10

Biomolecules, 2023
S100A10 (p11, annexin II light chain, calpactin light chain) is a multifunctional protein with a wide range of physiological activity. S100A10 is unique among the S100 family members of proteins since it does not bind to Ca2+, despite its sequence and ...
Gillian C. Okura, Alamelu G. Bharadwaj, David M. Waisman   +2 more
doaj   +1 more source

S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53

Open Medicine, 2020
S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC).
Song Dongqiang, Xu Beili, Shi Dongmin, Li Shuyu, Cai Yu   +4 more
doaj   +1 more source

Identification of new biomarkers of hepatic cancer stem cells through proteomic profiling [PDF]

Journal of Liver Cancer
Backgrounds/Aims In hepatocellular carcinoma (HCC), which exhibits high mortality and recurrence rates globally, the traits of cancer stem cells (CSCs) that significantly influence recurrence and metastasis are not well understood. CSCs are self-renewing
Sung Hoon Choi, Ha Young Lee, Sung Ho Yun, Sung Jae Jang, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Do Young Kim   +7 more
doaj   +1 more source