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Nature Reviews Cancer, 2015 In humans, the S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. This family of proteins modulates cellular responses by functioning both as intracellular Ca(2+) sensors and as extracellular factors.
Anne R Bresnick
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S100 Proteins in the Epidermis [PDF]
Journal of Investigative Dermatology, 2004 The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. Fourteen S100 protein genes are located within the epidermal differentiation complex on human chromosome 1q21 and 13 S100 proteins (S100A2, S100A3, S100A4, S100A6, S100A7, S100A8, S100A9 ...
Richard L Eckert +2 more
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S100 proteins in cardiovascular diseases
Molecular Medicine, 2023 AbstractCardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts.
Yue Zhou +5 more
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An update of the S100 nomenclature
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006 The plethora of names given to S100 proteins resulted in considerable confusion. Here we present the official and updated nomenclature of this protein family, approved by the HGNC (HUGO gene nomenclature committee) and ECS (European Calcium Society).
Marenholz, Ingo +2 more
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S100 and Cytokine Expression in Caries [PDF]
Infection and Immunity, 2004 ABSTRACT The molecular immune response of the pulpal tissue during chronic carious infection is poorly characterized. Our objective was to examine the expression of potential molecular mediators of pulpal inflammation, correlate their levels with disease severity, and determine the cellular localization of key molecules.
Julia L, McLachlan +4 more
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S100 Proteins in Alzheimer’s Disease [PDF]
Frontiers in Neuroscience, 2019 S100 proteins are calcium-binding proteins that regulate several processes associated with Alzheimer's disease (AD) but whose contribution and direct involvement in disease pathophysiology remains to be fully established. Due to neuroinflammation in AD patients, the levels of several S100 proteins are increased in the brain and some S100s play roles ...
Joana S. Cristóvão +3 more
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S100 proteins as therapeutic targets [PDF]
Biophysical Reviews, 2018 The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute to a broad array of intracellular and extracellular functions.
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S100 proteins in health and disease [PDF]
Amino Acids, 2010 One class of proteins that has been increasingly emerging as a potentially important group of both molecular key players and biomarkers in the etiology, progression, manifestation and therapy of various inflammatory, neurodegenerative, metabolic and neoplastic disorders is the S100 family.
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S100 Proteins in Acute Myeloid Leukemia
Neoplasia, 2018 The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell proliferation, cell differentiation, regulation of transcription factors, inflammation, chemotaxis, and angiogenesis. S100 proteins have in several types of cancer proven to be biomarkers for disease
Brenner, Annette, Bruserud, Øystein
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Olanzapine and S100 Proteins [PDF]
Neuropsychopharmacology, 2006 Hari, Manev, Radmila, Manev
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