Results 81 to 90 of about 131,599 (329)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

open access: yesAdvanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen   +7 more
wiley   +1 more source

Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]

open access: yes, 2009
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée   +2 more
core   +1 more source

Observations of Anomalous Microwave Emission from HII regions [PDF]

open access: yes, 2013
In this brief review, I give a summary of the observations of Anomalous Microwave Emission (AME) from HII regions. AME has been detected in, or in the vicinity of, HII regions.
Dickinson, Clive
core   +3 more sources

S100 proteins as therapeutic targets [PDF]

open access: yesBiophysical Reviews, 2018
The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute to a broad array of intracellular and extracellular functions.
openaire   +2 more sources

Enhancing Ion‐Electron Transport in Positive Electrode of Solid‐State Lithium Metal Batteries With Multifunctional Catholyte Made of Polymer Mixed Ionic‐Electronic Conductor PEDOT:PSSTFSI and Li3InCl6

open access: yesAdvanced Energy Materials, EarlyView.
A mixed ion‐electron conducting polymer binder, PEDOT:PSSTFSI, enhances both ionic and electronic transport in NMC‐based positive electrode composite (PEC) for ASSBs. Optimal polymer loading (0.33 wt.% in PEC) provides the most balanced transport, with an effective conductivities (σel/σion) ratio closest to unity, enabling high discharge capacity at 1 ...
Elina Nazmutdinova   +6 more
wiley   +1 more source

The criterion of supernova explosion revisited: the mass accretion history

open access: yes, 2015
By performing neutrino-radiation hydrodynamic simulations in spherical symmetry (1D) and axial symmetry (2D) with different progenitor models by Woosley & Heger (2007) from 12 $M_{\odot}$ to 100 $M_{\odot}$, we find that all 1D runs fail to produce an ...
Kotake, Kei   +3 more
core   +1 more source

Modular Electronic Microrobots With Onboard Sensor‐Program‐Steered Locomotion

open access: yesAdvanced Intelligent Systems, EarlyView.
Modular electronic smartlet microrobots integrate ambient‐light energy harvesting, photodetection, programmable CMOS control, and bubble‐based actuation within a sub‐millimeter fold‐up architecture. A 58‐bit on‐board CMOS chiplet enables sensor–program steered switching between independently addressable actuators, achieving closed‐loop 2D navigation in
Vineeth K. Bandari   +6 more
wiley   +1 more source

Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells

open access: yesScientific Reports, 2017
Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured.
Juha Piltti   +4 more
doaj   +1 more source

Hybrid methods in planetesimal dynamics: Formation of protoplanetary systems and the mill condition [PDF]

open access: yes, 2013
The formation and evolution of protoplanetary discs remains a challenge from both a theoretical and numerical standpoint. In this work we first perform a series of tests of our new hybrid algorithm presented in Glaschke, Amaro-Seoane and Spurzem 2011 ...
Amaro-Seoane, Pau   +2 more
core   +3 more sources

Research progress on biomarkers of traumatic brain injury

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen   +8 more
wiley   +1 more source

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