Results 91 to 100 of about 6,242 (166)

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

, 2012
Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking through the type 1 sphingosine 1-phosphate receptor (S1P1) and participates in many pathological conditions, including autoimmune diseases.
Takehiro Hirayama, Kayo Matsumoto, Nobue Harima, Tetsuo Takayama, Yasuyuki Igarashi, Hidenori Ohtake, Tomoyuki Inoue, Ryo Goitsuka, Naoya Ono, Yasuyuki Fujii, Shinya Hidano, Kiyoshi Nakazawa, Narutoshi Tsukahara, Takanobu Sakurai   +13 more
core   +1 more source

Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells [PDF]

, 2003
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, signals via G protein-coupled receptors (GPCR). The prototypical S1P receptor, S1P1 (also known as EDG-1), a Gi-linked receptor, is critical for vascular maturation during development.
Kluk, Michael J., Hla, Timothy, Ming-Tao Wu, Timothy Hla, Colmont, Chantal, Wu, Ming-Tao, Chantal Colmont, Michael J. Kluk   +7 more
core   +1 more source

AKP-11 mediated S1P1 down-regulation is Sphingosine kinase independent and AKP-11 induces less ubiquitinylation.

, 2015
(A-B) 10μM of SPKII, a dual sphingosine kinase inhibitor treated in CHO-S1P1-HA stable cells for 30 min. After that, the cells were stimulated with 100 nM AKP-11 or FTY720, or FTY720P for 1 hr.
Avtar K. Singh (819945), Inderjit Singh (33771), Gurmit S. Gill (819946), Nishant Saxena (308963), Damian W. Grobelny (819947), Jasdeep S. Dhindsa (819944), Devadoss J. Samuvel (327215)   +6 more
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Studies on expression and function of sphingosine 1-phosphate receptor-1 (S1P1) in embryogenesis and the adult

, 2004
S1P1, a high affinity G-protein coupled receptor for bioactive lipid sphingosine 1-phosphate (S1P), regulates various cellular functions. However, little is known about the physiological roles of S1P1. To improve our understanding of the function of S1P1
Chae, Sung-Suk
core   +1 more source

Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice

Frontiers in Immunology, 2017
Sphingosine-1-phosphate (S1P) levels significantly increase in bronchoalveolar lavage (BAL) of asthmatic patients following segmental allergen challenge and this increase well correlates with pulmonary inflammation.
Fiorentina Roviezzo, Rosalinda Sorrentino, Michela Terlizzi, Maria Antonietta Riemma, Valentina Mattera Iacono, Antonietta Rossi, Giuseppe Spaziano, Aldo Pinto, Bruno D’Agostino, Giuseppe Cirino   +9 more
doaj   +1 more source

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

, 2015
The sphingosine 1-phosphate receptor 1 (S1P1) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function.
Dahlbäck, Björn, Conger, Heather, Blaho, Victoria A, Kono, Mari, Sanson, Marie, Smith, Jonathan D, Hla, Timothy, Dahlbäck, Björn,, Galvani, Sylvain, Proia, Richard L, Swendeman, Steven L, Lund University.   +11 more
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Role of sphingosine-1-phosphate receptor 1 and downstream heme oxygenase-1 induction in alternative macrophage activation induced by apoptotic cells [PDF]

, 2010
Macrophages show a remarkable functional plasticity, which enables them to change their phenotype in response to environmental signals. They are key players during infection by initiating inflammation through the release of proinflammatory mediators ...
Weis, Nicole
core  

Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis

Japanese Dental Science Review, 2019
Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium.
Islamy Rahma Hutami, Eiji Tanaka, Takashi Izawa   +2 more
doaj   +1 more source

Premature egress of B cell precursors from the BM of S1P1-transgenic mice.

, 2013
(A) Quantitative RT-PCR analysis of the expression of S1P1 encoding mRNA in purified developing BM B cell subsets from S1P1-transgenic (gray bars) and littermate control (white bars) mice, presented relative to Hprt1 mRNA (hypoxanthine guanine ...
Jason G. Cyster (160534), Ying Xu (9172), João Pedro Pereira (366887)   +2 more
core   +1 more source

Effect of FTY720 on the vascular expression of S1P1 and S1P2.

, 2016
Rats were treated for 6 weeks with 1mg/kg FTY720 or vehicle. S1P1 and S1P2 expression was assessed in renal resistance arteries (A) S1P1 staining (red) in vascular smooth muscle of renal resistance arteries is reduced by FTY720 treatment.
Hendrik Buikema (128836), Arash Bidadkosh (3095325), Leo E. Deelman (128834), Robert H. Henning (108507), Mahdi Hamidi Shishavan (3095328), Saleh Yazdani (297333), Jacob van den Born (167146), Sebastiaan Lambooy (3095322)   +7 more
core   +1 more source