Results 81 to 90 of about 6,242 (166)

Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

Pulmonary Circulation, 2020
Rationale Vascular permeability is a hallmark of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury pathobiology; however, the mechanisms underlying this vascular dysregulation remain unclear, thereby impairing the development ...
Sara M. Camp, Alexander Marciniak, Eddie T. Chiang, Alexander N. Garcia, Robert Bittman, Robin Polt, Ruth G. Perez, Steven M. Dudek, Joe G. N. Garcia   +8 more
doaj   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Effect of FTY720 on the expression of S1P1 and S1P2 in cultured human endothelial cells (HUVEC).

, 2016
(A) Western blot of S1P1 and S1P2 expression in cultured endothelial cells in control and HUVEC cells treated with 10μM FTY720 for 24 hours.(B) Quantification of S1P1 and S1P2 blot.
Hendrik Buikema (128836), Arash Bidadkosh (3095325), Leo E. Deelman (128834), Robert H. Henning (108507), Mahdi Hamidi Shishavan (3095328), Saleh Yazdani (297333), Jacob van den Born (167146), Sebastiaan Lambooy (3095322)   +7 more
core   +1 more source

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism [PDF]

, 2006
After induction in secondary lymphoid organs, a subset of antibody-secreting cells (ASCs) homes to the bone marrow (BM) and contributes to long-term antibody production.
Ying Xu, Kabashima, K, Allende, Maria L, Nicole M. Haynes, Xu, Y, Cyster, Jason G, Allende, ML, Proia, RL, Kenji Kabashima, Nutt, SL, Cyster, JG, Haynes, Nicole M, Jason G. Cyster, Nutt, Stephen L, Stephen L. Nutt, Kabashima, Kenji, Xu, Ying, Proia, Richard L, Haynes, NM, Maria L. Allende, Richard L. Proia   +20 more
core   +1 more source

Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors

, 2004
International audienceThe sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G protein coupled receptors,termed S1P1 (formerly Endothelial Differentiation Gene-1, Edg-1), S1P2 (Edg-5), S1P3 (Edg-3), S1P4(Edg-6) and S1P5 (edg-8), and ...
Blondeau, Nicolas, Waeber, Christian, Salomone, Salvatore   +2 more
core   +1 more source

AKP-11 withdrawal increases cell surface S1P1 receptor expression.

, 2015
(A-B) CHO cells expressing S1P1-HA were pretreated with cycloheximide (15μg/ml) for 30 min to block the synthesis of new S1P1 and then stimulated with 100 nM AKP-11 or FTY720 or FTY720P for 1 hr.
Avtar K. Singh (819945), Inderjit Singh (33771), Gurmit S. Gill (819946), Nishant Saxena (308963), Damian W. Grobelny (819947), Jasdeep S. Dhindsa (819944), Devadoss J. Samuvel (327215)   +6 more
core   +1 more source

FTY720-induced antinociception in the chronic constrictive injury (CCI) mouse model: neuronal-astroglial mechanisms through S1P1 signaling

, 2021
Novel pharmacological and genetic advancements increased interest in the sphingosine-1-phosphate receptor-1 (S1P1) as a potential therapeutic target.
Moncayo, Lauren V
core   +1 more source

Novel vanillin or sulfanilamide derivatives as potential lymphocyte-reducing agents for multiple sclerosis: Design, synthesis, molecular docking, and biological evaluation

Results in Chemistry
Multiple sclerosis (MS) is a chronic autoimmune disorder in which deregulated migration of immune cells leads to demyelination in the central nervous system.
Ghadamali Khodarahmi, Naeime Razghandi, Leila Safaeian, Farshid Hassanzadeh, Parvin Asadi   +4 more
doaj   +1 more source

Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

Frontiers in Molecular Neuroscience, 2017
The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration.
Serena Quarta, Maria Camprubí-Robles, Rüdiger Schweigreiter, Dusan Matusica, Rainer V. Haberberger, Richard L. Proia, Christine E. Bandtlow, Antonio Ferrer-Montiel, Michaela Kress   +8 more
doaj   +1 more source

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

, 2016
Stipo Jurcevic,1 Pierre-Eric Juif,2 Colleen Hamid,3 Roseanna Greenlaw,3 Daniele D’Ambrosio,2 Jasper Dingemanse2 1Department of Biomedical Sciences, University of Westminster, London, UK; 2Department of Clinical Pharmacology, Actelion ...
Jurcevic S, Dingemanse J, D'Ambrosio D, Hamid C, Juif PE, Greenlaw R   +5 more
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