Results 61 to 70 of about 6,242 (166)

S1P1, S1P3, and PKCβII mRNA expression analysis of cardiac microvessels.

, 2013
Up-regulation of S1P3 and PKCβII or down-regulation of S1P1 in DM differed significantly from controls ...
Haichang Wang (311500), Linni Fan (311497), Liping Wei (10166), Rongqing Zhang (168798), Zhiyong Yin (311496), Feng Cao (38032), Ling Tao (311499), Haokao Gao (311498)   +7 more
core   +1 more source

A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis

Journal of Inflammation, 2020
Background Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseases threatening public health ...
Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong, Heeyeong Cho   +10 more
doaj   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease [PDF]

, 2016
The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 ...
Sarkisyan, G, Rosen, H, González-Cabrera, P, Veny, M, Boyer, JD, Bamias, G, Peach, R, Clark, D, Gima, L, Jedlicka, P, Behrens, E-H, Karuppuchamy, T, Scott, F, Rivera-Nieves, J   +13 more
core   +1 more source

Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-α

Journal of Lipid Research, 2008
Sphingosine-1-phosphate (S1P), via interaction with its G protein-coupled receptors, regulates various physiological and pathological responses. The present study investigated the role of S1P/S1P receptor signaling in several functional responses of ...
Chenqi Zhao, Maria J. Fernandes, Mélanie Turgeon, Sabrina Tancrède, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin   +6 more
doaj   +1 more source

Effects of Selective Sphingosine‐1‐Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four‐Way Cross‐Over Study in Healthy Volunteers

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Introduction Preclinical evidence suggests that dysregulation of the ceramide‐sphingosine‐1‐phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia.
Wouter A. Bakker, P. Eijsvogel, Erica S. Klaassen, Jessica Kim, Ruihua Chen, Mark A. Demitrack, Albert Dahan, Marieke Niesters, Hemme J. Hijma, Geert Jan Groeneveld   +9 more
wiley   +1 more source

CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate

Frontiers in Immunology, 2018
The signal mediated by sphingosine-1-phosphate receptor 1 (S1P1) is essential but seemingly insufficient for thymic export of newly generated T cells. Here, we reported the identification of CCR2 as an additional regulator of this process.
Abudureyimujiang Aili, Jie Zhang, Jia Wu, Haoming Wu, Xiuyuan Sun, Qihua He, Rong Jin, Yu Zhang, Yu Zhang   +8 more
doaj   +1 more source

Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus

RMD Open, 2020
Objectives: SLE is an autoimmune disease characterised by aberrant lymphocyte activation and autoantibody production. This study provides an in-depth preclinical and clinical characterisation of the treatment effect of cenerimod, a sphingosine-1 ...
Daniel S Strasser, Estelle Gerossier, Virginie Sippel, Ursula Grieder, Andrea Kieninger-Graefitsch, Sylvie Froidevaux, Marten Trendelenburg, Gabin M Pierlot, Enrico Vezzali, Anna K Stalder, Bérengère Renault, Jesper Ryge, Aaron Hart, Ulrich Mentzel, Peter M A Groenen, Marcel P Keller, Marianne M Martinic, Mark J Murphy   +17 more
doaj   +1 more source

PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT Multiple sclerosis (MS) is a significant cause of neurological disability in young adults. Siponimod, a potent sphingosine‐1‐phosphate (S1P) receptor modulator, is used to treat MS by reducing T‐cell recirculation and central inflammation. The presented work includes clinical data describing the impact of the CYP3A4 inhibitor clarithromycin on
Felix Huth, Kasra Shakeri‐Nejad, Anne Gardin, Bharti Shah, Oliver Pohl, Nicole Pezous, Thomas Faller   +6 more
wiley   +1 more source

CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation

Nature Communications, 2018
CD69 competes with S1P1, a chemokine receptor mediating thymocyte egress, for surface expression on thymocytes, but whether CD69 is required for normal thymic development is unclear.
Motoko Y. Kimura, Akemi Igi, Koji Hayashizaki, Yukiyoshi Mita, Miho Shinzawa, Tejas Kadakia, Yukihiro Endo, Satomi Ogawa, Ryoji Yagi, Shinichiro Motohashi, Alfred Singer, Toshinori Nakayama   +11 more
doaj   +1 more source