Results 41 to 50 of about 6,242 (166)

Defective sphingosine-1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation [PDF]

, 2014
Sphingosine-1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. Sphingosine phosphate receptor 1 (S1P1) agonist, FTY-720 (Gilenya™) arrests immune trafficking and prevents multiple sclerosis (MS ...
Wu, Linfeng, Han, David K., Huang, Yingxiang, Axtell, Robert C., Lewis, David B., Steinman, Lawrence, Moon, Byoung San, Hla, Timothy, Blaho, Victoria A., Sobel, Raymond A., Steinberg, Gary K., Snyder, Michael P., Garris, Christopher, Ho, Peggy P., Arac, Ahmet, Han, May H., Acharya, Swati   +16 more
core   +1 more source

Redox‐Neutral Vicinal Dialkylation of Aryl Boronic Esters via the Palladium/Norbornene Cooperative Catalysis

Angewandte Chemie International Edition, EarlyView.
A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye, Peimiao He, Liyan Kan, Thomas R. Plambeck, Guangbin Dong   +4 more
wiley   +1 more source

The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen

, 2011
Sphingosine-1-phosphate (S1P) has been implicated in angiogenesis, inflammation, cancerogenesis, neurological excitability and immune regulation and is synthesized by two different sphingosine kinases (SphK).
Matthias Schröder, Oliver Giegold, Giegold, Oliver, Schröder, Matthias, Josef M. Pfeilschifter, Huwiler, Andrea, Radeke, Heinfried H, Juan, Martina Herrero San, Pfeilschifter, Josef M, Richter, Cornelia, Martina Herrero San Juan, Heinfried H. Radeke, Katrin Maltusch, Gianluca Quintini, Cornelia Richter, Maltusch, Katrin, Andrea Huwiler, Quintini, Gianluca   +17 more
core   +1 more source

Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions[S]

Journal of Lipid Research, 2014
Sphingosine 1-phosphate receptor 1 (S1P1), an abundantly-expressed G protein-coupled receptor which regulates key vascular and immune responses, is a therapeutic target in autoimmune diseases. Fingolimod/Gilenya (FTY720), an oral medication for relapsing-
Hideru Obinata, Sarah Gutkind, Jeremiah Stitham, Toshiaki Okuno, Takehiko Yokomizo, John Hwa, Timothy Hla   +6 more
doaj   +1 more source

Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator. [PDF]

PLoS ONE, 2013
Ponesimod, a selective S1P1 receptor modulator, reduces the blood lymphocyte count in all tested species by preventing egress of T and B cells from thymus and peripheral lymphoid organs.
Markus Rey, Patrick Hess, Martine Clozel, Stéphane Delahaye, John Gatfield, Oliver Nayler, Beat Steiner   +6 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease. [PDF]

PLoS ONE, 2012
BACKGROUND: Diabetes is associated with an increased risk of cardiac microvascular disease. The mechanisms by which this damage occurs are unknown. However, research suggests that signaling through the sphingosine-1-phosphates receptor 1 and 3 (S1P1/3 ...
Zhiyong Yin, Linni Fan, Liping Wei, Haokao Gao, Rongqing Zhang, Ling Tao, Feng Cao, Haichang Wang   +7 more
doaj   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

AKP-11 decreases cell surface expression of S1P1 receptor.

, 2015
(A-C) CHO cells were stably transfected with S1P1-HA constructs and treated for 2hrs with 10 or 100 or 1000nM of AKP-11 or FTY720 or FTY720P. Cell surface S1P1 HA was carried out by biotinylation method.
Avtar K. Singh (819945), Inderjit Singh (33771), Gurmit S. Gill (819946), Nishant Saxena (308963), Damian W. Grobelny (819947), Jasdeep S. Dhindsa (819944), Devadoss J. Samuvel (327215)   +6 more
core   +1 more source

Blood Flow Restriction Training in Stroke Rehabilitation: A Narrative Review of Current Evidence and Future Directions

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Post‐stroke motor deficits cause disability, while paresis and comorbidities may limit high‐intensity training. Blood flow restriction training (BFRT) combines low‐intensity exercise with partial vascular occlusion and may promote neuromuscular adaptations at low loads.
Jiawei Tong, Lei Song, Juan Jin, Fangfang Li, Tao Huang, Hang Ying, Jiawei Zhu, Jue Wang, Jie Zhuang   +8 more
wiley   +1 more source