Results 21 to 30 of about 6,242 (166)

Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy

Cells, 2021
Destruction of alveoli by apoptosis induced by cigarette smoke (CS) is a major driver of emphysema pathogenesis. However, when compared to cells isolated from non-smokers, primary human lung microvascular endothelial cells (HLMVECs) isolated from chronic
Khushboo Goel, Erica L. Beatman, Nicholas Egersdorf, April Scruggs, Danting Cao, Evgeny V. Berdyshev, Kelly S. Schweitzer, Irina Petrache   +7 more
doaj   +1 more source

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. [PDF]

, 2021
Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors.
Imeri, Faik, Kleuser, Burkhard (Prof. Dr. rer. nat.), Homann, Thomas, Zivkovic, Aleksandra (Dr.), Stark, Holger, Bisera Stepanovska Tanturovska, Homann, Thomas (Dr.), Kleuser, Burkhard, Huwiler, Andrea, Holger Stark, Burkhard Kleuser, Stepanovska Tanturovska, Bisera, Thomas Homann, Faik Imeri, Zivkovic, Aleksandra, Aleksandra Zivkovic, Andrea Huwiler, Tanturovska, Bisera Stepanovska   +17 more
core   +2 more sources

MiR-9 Promotes Angiogenesis via Targeting on Sphingosine-1- Phosphate Receptor 1

Frontiers in Cell and Developmental Biology, 2020
We previously demonstrated that vascular endothelial cells released VEGF-enriched exosomes to promote the tumor vasculogenesis and progression after anti-angiogenic therapies (AATs).
Xinghong Yao, Xinghong Yao, Linshen Xie, Ye Zeng   +3 more
doaj   +1 more source

Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1–3 in angiogenesis [PDF]

, 2002
In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1-phosphate receptor genes (lpa1–3 and s1p1–5, respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization ...
Beth Friedman, Contos, James J.A, McGiffert, Christine, James J.A Contos, Chun, Jerold, Jerold Chun, Friedman, Beth, Christine McGiffert   +7 more
core   +1 more source

Prolonging survival of corneal transplantation by selective sphingosine-1-phosphate receptor 1 agonist. [PDF]

PLoS ONE, 2014
Corneal transplantation is the most used therapy for eye disorders. Although the cornea is somewhat an immune privileged organ, immune rejection is still the major problem that reduces the success rate.
Min Gao, Yong Liu, Yang Xiao, Gencheng Han, Liang Jia, Liqiang Wang, Tian Lei, Yifei Huang   +7 more
doaj   +1 more source

Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis. [PDF]

, 2020
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central nervous system (CNS) which is associated with lower life expectancy and disability.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Stepanovska, Bisera, Engelhardt, Britta (Prof. Dr.), Homann, Thomas, Bisera Stepanovska, Gaby Enzmann, Zivkovic, Aleksandra (Dr.), Engelhardt, Britta, Stark, Holger, Britta Engelhardt, Homann, Thomas (Dr.), Kleuser, Burkhard, Huwiler, Andrea, Holger Stark, Burkhard Kleuser, Tietz, Silvia, Enzmann, Gaby, Thomas Homann, Zivkovic, Aleksandra, Aleksandra Zivkovic, Andrea Huwiler, Huwiler, Andrea (Prof. Dr.), Silvia Tietz   +22 more
core   +2 more sources

Non-Mitogenic Fibroblast Growth Factor 1 Enhanced Angiogenesis Following Ischemic Stroke by Regulating the Sphingosine-1-Phosphate 1 Pathway

Frontiers in Pharmacology, 2020
Ischemic strokes account for about 80% of all strokes and are associated with a high risk of mortality. Angiogenesis of brain microvascular endothelial cells may contribute to functional restoration following ischemia.
Yuchi Zou, Jian Hu, Wenting Huang, Shasha Ye, Fanyi Han, Jingting Du, Mingjie Shao, Ruili Guo, Jingjing Lin, Yeli Zhao, Yeli Zhao, Ye Xiong, Xue Wang, Xue Wang   +13 more
doaj   +1 more source

ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. [PDF]

PLoS ONE, 2014
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that acts through the members of a family of five G protein-coupled receptors (S1P1-S1P5).
Rie Yamamoto, Youhei Okada, Jun Hirose, Tadatsura Koshika, Yuka Kawato, Masashi Maeda, Rika Saito, Kazuyuki Hattori, Hironori Harada, Yasuhisa Nagasaka, Tatsuaki Morokata   +10 more
doaj   +1 more source

Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5

Frontiers in Pharmacology, 2022
Ozanimod, a sphingosine 1-phosphate (S1P) receptor modulator, binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), and is approved in multiple countries for treating adults with relapsing forms of multiple sclerosis (MS ...
Julie V. Selkirk, Andrea Bortolato, Yingzhuo Grace Yan, Nathan Ching, Richard Hargreaves   +4 more
doaj   +1 more source

Data_Sheet_1_In silico Docking Studies of Fingolimod and S1P1 Agonists.docx

, 2020
The sphingosine-1-phosphate receptor 1 (S1P1), originally the endothelial differentiation gene 1 receptor (EDG-1), is one of five G protein–coupled receptors (GPCRs) S1P1–5 that bind to and are activated by sphingosine-1-phosphate (S1P). The lipid S1P is
Alexander Marciniak (8553261), Sara M. Camp (3148308), Joe G. N. Garcia (7923365), Robin Polt (1313058)   +3 more
core   +1 more source