FEBS Open Bio, 2020 Sphingosine‐1 phosphate receptor‐1 (S1P1) activation maintains endothelial barrier integrity, whereas S1P1 desensitization induces peripheral blood lymphopenia.
Patrick Grailhe, Ashfaq A. Parkar
exaly +2 more sources
'I Call Them Our Village': Experiences Of Caregivers in Ontario's Extensive Needs Service. [PDF]
Child Care Health DevABSTRACT Background Children and youth with complex needs, including neurodevelopmental disabilities or acquired brain injuries and co‐occurring mental health and physical health diagnoses, often experience difficulties accessing care that they need.
Rombos V +12 more
europepmc +2 more sources
Regulation of CXCR4 function by S1P1 through heteromerization [PDF]
Cell Communication and SignalingBackground The trafficking of immune cells between lymphoid organs and circulation depends on gradients of CXCL12 and sphingosine-1-phosphate (S1P), mediated through their cognate receptors C-X-C chemokine receptor type 4 (CXCR4) and S1P receptor type 1 (
Hyun-Tae Kim, Jae-Yeon Jeong, Won-Ki Huh
doaj +2 more sources
HDL from patients with type 2 diabetes impairs endothelial function by inducing ferroptosis via nuclear receptor coactivator 4 [PDF]
Journal of Lipid ResearchEndothelial function is impaired in patients with diabetes. Normal high-density lipoprotein (nHDL) protects endothelial function; however, HDL from patients with diabetes becomes dysfunctional (dHDL) and impairs endothelial function.
Zhen-Sheng Ma +10 more
doaj +2 more sources
The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis. [PDF]
Acta Physiol (Oxf)ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Kazanis I +4 more
europepmc +2 more sources
Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeability [PDF]
MedCommSepsis is a life‐threatening disease characterized by multiorgan dysfunction caused by an abnormal immune response to microbial infection. Sphingosine‐1‐phosphate (S1P) levels are significantly lower in patients with sepsis and are negatively correlated ...
Suhong Duan +11 more
doaj +2 more sources
Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2 [PDF]
Cell Death and DiseaseSphingosine-1-phosphate (S1P) has been implicated in promoting breast cancer progression, but its role in fostering an immunosuppressive microenvironment remains largely unexplored.
Avinandan Bhoumick +8 more
doaj +2 more sources
Exogenous Plant Growth-Promoting Rhizobacteria Enhance the Promoting Effect of Polyaspartic Acid on Potato Growth by Improving Rhizosphere Nutrient Availability and Reshaping Microbial Community [PDF]
PlantsPolyaspartic acid (PASP), a biodegradable and eco-friendly fertilizer synergist that shows potential to enhance nutrient use efficiency in agricultural systems, has its integrative role with rhizosphere microorganisms remain insufficiently explored. This
Xin Zhou +7 more
doaj +2 more sources
Sphingosine 1-phosphate receptor 1 signaling in macrophages reduces atherosclerosis in LDL receptor–deficient mice [PDF]
JCI InsightSphingosine 1-phosphate (S1P) is a lysosphingolipid with antiatherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet–fed LDL receptor–deficient mice with high
Francesco Potì +19 more
doaj +2 more sources
Unique pharmacological properties of etrasimod among S1P receptor modulators [PDF]
FEBS Open BioEtrasimod (ADP334) is an oral, once‐daily, selective sphingosine 1‐phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis and in development for the treatment of immune‐mediated inflammatory diseases.
Ibragim Gaidarov +18 more
doaj +2 more sources