Results 31 to 40 of about 6,242 (166)

Palmitoylation of the sphingosine 1-phosphate receptor S1P1 is involved in its signaling functions and internalization [PDF]

, 2009
The lipid mediator sphingosine 1-phosphate (S1P) regulates several cellular processes through binding to its receptors (S1P1-S1P5), which are heterotrimeric G protein-coupled receptors. Here, we report that all S1P receptors are palmitoylated.
Ohno, Yusuke, Yusuke Ohno, Akio Kihara, Ren Ogata, Hiraga, Yuki, Ogata, Ren, Igarashi, Yasuyuki, Yuki Hiraga, Ito, Ayako, Yasuyuki Igarashi, Kihara, Akio, Ayako Ito   +11 more
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Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors.

PLoS ONE, 2019
Although sphingosine-1-phosphate receptor 1 (S1P1) has been shown to trigger several S1P targeted functions such as immune cell trafficking, cell proliferation, migration, or angiogenesis, tools that allow the accurate detection of endogenous S1P1 ...
Franck Talmont, Lionel Moulédous, Marion Baranger, Anne Gomez-Brouchet, Jean-Marie Zajac, Clarence Deffaud, Olivier Cuvillier, Anastassia Hatzoglou   +7 more
doaj   +1 more source

S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity

Journal of Lipid Research, 2013
Signaling through sphingosine-1-phosphate receptor1 (S1P1) promotes blood vessel barrier function. Degradation of S1P1 results in increased vascular permeability in the lung and may explain side effects associated with administration of FTY720, a ...
David C. Montrose, Ellen J. Scherl, Brian P. Bosworth, Xi Kathy Zhou, Bongnam Jung, Andrew J. Dannenberg, Timothy Hla   +6 more
doaj   +1 more source

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis [PDF]

, 2012
SummaryLymphocyte trafficking is critically regulated by the Sphingosine 1-phosphate receptor-1 (S1P1), a G protein-coupled receptor that has been highlighted as a promising therapeutic target in autoimmunity.
Bigaud, Marc, Seabrook, Tim, Smith, Paul A., Streiff, Markus, Berst, Frédéric, Buehlmayer, Peter, Seabrook, Timothy J., Seuwen, Klaus, Hersperger, René, Smith, Paul, Quancard, Jean, Bollbuck, Birgit, Beerli, Christian, Bassilana, Frédéric, Brinkmann, Volker, Guerini, Danilo, Traebert, Martin, Angst, Daniela, Janser, Philipp, Bruns, Christian   +19 more
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Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundSphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine‐1‐phosphate receptor 1 (S1P1) in vivo is unknown. Methods
Petra Keul, Marcel M. G. J. van Borren, Alexander Ghanem, Frank Ulrich Müller, Antonius Baartscheer, Arie O. Verkerk, Frank Stümpel, Jan Sebastian Schulte, Nazha Hamdani, Wolfgang A. Linke, Pieter van Loenen, Marek Matus, Wilhelm Schmitz, Jörg Stypmann, Klaus Tiemann, Jan‐Hindrik Ravesloot, Astrid E. Alewijnse, Sven Hermann, Léon J. A. Spijkers, Karl‐Heinz Hiller, Deron Herr, Gerd Heusch, Michael Schäfers, Stephan L. M. Peters, Jerold Chun, Bodo Levkau   +25 more
doaj   +1 more source

A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models

Acta Pharmaceutica Sinica B, 2020
Psoriasis is characterized by abnormal proliferation of keratinocytes, as well as infiltration of immune cells into the dermis and epidermis, causing itchy, scaly and erythematous plaques of skin.
Jing Jin, Nina Xue, Yuan Liu, Rong Fu, Mingjin Wang, Ming Ji, Fangfang Lai, Jinping Hu, Xiaojian Wang, Qiong Xiao, Xiaoying Zhang, Dali Yin, Liping Bai, Xiaoguang Chen, Shuan Rao   +14 more
doaj   +1 more source

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress [PDF]

, 2008
SummaryThe mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promote lymphocyte egress from lymphoid organs is not defined. Here, we showed that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did, whereas ...
Okada, Takaharu, Pham, Trung H.M., Mehrdad Matloubian, Trung H.M. Pham, Lo, Charles G., Cyster, Jason G., Takaharu Okada, Charles G. Lo, Matloubian, Mehrdad, Jason G. Cyster   +9 more
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S1P1, S1P3, and PKCβII protein expression analysis of CMECs.

, 2013
Compared with control, we detected a significant decrease of S1P1 and increase of PKCβII in HG group. Meanwhile, a coincidence of increased membrane and decreased nuclear expression of S1P3 was found, suggesting a S1P3 translocation induced by glucose ...
Haichang Wang (311500), Linni Fan (311497), Liping Wei (10166), Rongqing Zhang (168798), Zhiyong Yin (311496), Feng Cao (38032), Ling Tao (311499), Haokao Gao (311498)   +7 more
core   +1 more source

S1P1 deletion differentially affects TH17 and Regulatory T cells

, 2017
Sphingosine-1 phosphate receptor 1 (S1P1) is critical for the egress of T and B cells out of lymphoid organs. Although S1P1 agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P1 signaling regulates ...
Mariko Kita, Rebekka Duhen, Ahmet Eken, Akhilesh K. Singh, Jane H. Buckner, Mohamed Oukka, Mallory Fry, Estelle Bettelli   +7 more
core   +1 more source

Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways

Stem Cell Research, 2014
Although recent findings showed that the bioactive lipid metabolites can regulate the ES cell functions, the physiological relevance of interaction between sphingosine-1-phosphate (S1P) and Flk-1 and its related signaling molecules are not yet clear in ...
Jung Min Ryu, Young Bin Baek, Myung Sun Shin, Ji Hoon Park, Soo Hyun Park, Jang Hern Lee, Ho Jae Han   +6 more
doaj   +1 more source