Results 101 to 110 of about 6,242 (166)

Pharmacological blockade of G-protein coupled receptors : interventions to alter expression or internalization [PDF]

, 2004
Hangartner, Christoph
core   +1 more source

Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies

Scientific Reports
Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health.
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara   +11 more
doaj   +1 more source

HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver

, 2016
Regeneration of hepatic sinusoidal vasculature is essential for non-fibrotic liver regrowth and restoration of its metabolic capacity. However, little is known about how this specialized vascular niche is regenerated.
Chen, Yutian,, Hla, Timothy, Chen, Yutian, Ding, Bi-Sen,, Sun, Yue,, Lars Bo Nielsen, Chavez, Deebly,, Catherine H. Liu, Shahin Rafii, Schwab, Susan R, Rafii, Shahin, Jung, Bongnam, Rafii, Shahin,, Christoffersen, Christina, Christina Christoffersen, Bongnam Jung, Steven L. Swendeman, Sun, Yue, Christoffersen, Christina,, Bi-Sen Ding, Ding, Bi-Sen, Swendeman, Steven L.,, Yue Sun, Deebly Chavez, Jung, Bongnam,, Hla, Timothy,, Susan R. Schwab, Cao, Zhongwei, Cao, Zhongwei,, Chavez, Deebly, Yutian Chen, Liu, Catherine H.,, Timothy Hla, Nielsen, Lars Bo, Zhongwei Cao, Liu, Catherine H, Swendeman, Steven L, Nielsen, Lars Bo,, Schwab, Susan R.,   +38 more
core   +1 more source

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

, 2009
Targeting sphingosine-1-phosphate receptors with the oral immunomodulator drug FTY720 (fingolimod) has demonstrated substantial efficacy in the treatment of multiple sclerosis.
Florian Mullershausen, Danilo Guerini, Seuwen, Klaus, Muellershausen, Florian, Cetin, Cihan, Cihan Cetin, Klaus Seuwen, Andreas Billich, Guerini, Danilo, Zecri, Frederic, Frédéric Zecri, Billich, Andreas   +11 more
core   +1 more source

An oral S1P1 antagonist prodrug with efficacy in vivo: discovery, synthesis and evaluation

, 2012
A prodrug approach to optimize the oral exposure of an S1P1 antagonist for chronic efficacy studies led to the discovery of (S)-2-{[3'-(4-Chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carbonyl]-methyl-amino}-4-dimethylamino-butyric ...
Bassilana, Frederic, Bollbuck, Birgit, Quancard, Jean, Beerli, Christian, Streiff, Markus, Oberer, Lukas, Angst, Daniela, Janser, Philipp, Buehlmayer, Peter, Pally, Charles, Berst, Frederic   +10 more
core   +1 more source

The Effects of Tyrosine Sulfation of S1P1 on Human Endothelial Cell Migration

, 2010
鞘氨酸 1-磷酸鹽（Sphingosine 1-phosphate, S1P）是一種小分子磷脂質類生長因子，主要由發炎反應過程中活化的血小板所分泌，可調控許多重要的細胞生理功能，如促使細胞增生、分化與移行。而許多癌細胞在生長的過程中，也會釋放出S1P調控腫瘤的生成，並促使血管新生。S1P會與細胞上內皮細胞分化基因（edg）族中的G蛋白接合型受器接合，藉此調節多種訊息傳遞路徑。已知內皮細胞會表現三種已知Edg受器－Edg1（S1P1）、Edg2、和Edg3（S1P3），其中S1P1對於細胞的爬行 ...
林曉聖, Lin, Hsiao-Sheng
core  

Neuroprotective crosstalk from vitamin B12 and sphingolipid signaling pathways in therapy for multiple sclerosis. [PDF]

Int Immunol
Kihara Y, Chun J.
europepmc   +1 more source

Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3. [PDF]

Protein Cell
Wu Y, Chen Q, Wang H, Liu K, Wei J, Wang M, Chen K, Zhu Y, Han S, Yi C, Ma L, Schnapp G, Pautsch A, Gnamm C, Grauert M, Schmidt E, Tan Q, Wu B, Zhao Q.   +18 more
europepmc   +1 more source

Sodium alginate-poly(vinyl pyrrolidone) pH-responsive hydrogels for controlled release of tinidazole. [PDF]

RSC Adv
Jebessa ZF, Bayisa Bedasa T, Edossa GD, Guta Inki L, Amenu Abdi G, Woya BA.   +5 more
europepmc   +1 more source

Structural Characterization, Toxicity Assessment and Molecular Modeling of Forced Degradation Products of Siponimod. [PDF]

Int J Mol Sci
Liang Y, Zhang T, Zhang D, Jin B, Ma C.
europepmc   +1 more source