Results 201 to 210 of about 31,876,445 (280)

Broad environmental adaptation is associated with root anatomical phenotypes in maize landraces: an in silico study. [PDF]

Ann Bot
Lopez-Valdivia I, Rangarajan H, Vallebueno-Estrada M, Lynch JP.   +3 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The digital bioeconomy: microbiomes as a stress test for global digital sequence information governance. [PDF]

Sustain Microbiol
Pélissier PM, Karciauskaité I, Kostic T, Maguin E, Sessitsch A, Shiraishi K.   +5 more
europepmc   +1 more source

Selective Catalytic Production of Urea: Unravelling the Pairwise Competition on p‐d Alloy Catalysts

Advanced Science, EarlyView.
Unraveling the complicated competition in urea electrosynthesis, this work investigates asymmetric p‐d alloys. We establish two stage‐specific descriptors, Anchoring Affinity and Coupling Propensity, to elegantly quantify thermodynamic bottlenecks.
Qingchao Fang, Yun Han, Md Tarikal Nasir, Fuyong Qin, Wanhu Tian, Hanqing Yin, Aijun Du   +6 more
wiley   +1 more source

Genetic structure and selection signatures of Beijing-You chicken populations provide insight into breed conservation. [PDF]

Poult Sci
Gu H, Tang S, Wang X, Li Y, Yin Z, Chen X, Zeng L, Lin X, Chen J, Hou Z, Liu H, Luan R, Chu Q, Yang Y.   +13 more
europepmc   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Synthesis and Characterization of 2-(1-Hydroxyethyl)Promazine Sulfoxide-d₄ HCl as an Internal Standard for the Accurate Quantitation of 2-(1-Hydroxyethyl)Promazine Sulfoxide in Equine Urine. [PDF]

J Labelled Comp Radiopharm
Holmes JC, Smith BC, Awuah SG, Eisenberg R, Lehner AF, Fenger CK, Maylin GA, Brewer K, Tobin T.   +8 more
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Robust cross-immunity against a heterologous field strain of foot-and-mouth disease virus achieved in small ruminants following commercial vaccination in Jordan. [PDF]

Front Vet Sci
Foglia EA, Maccabiani G, van Maanen C, Tranquillo V, Bennour EM, Mansour HA, Osman NA, Khalifeh M, Yousif AA, Al-Ameer M, Bin-Tarif MS, Salah S, Lafi S, Hijazeen ZSK, Ramadneh WA, Baiomy S, Ambrosini F, Sammin D, Rosso F, Grazioli S.   +19 more
europepmc   +1 more source