Results 31 to 40 of about 247,572 (236)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Characterization of Volcanic Ash Influence on the Nutritional Quality and Biological Traits in Potato Crops of the Cotopaxi Region

Toxics
This study investigates the impact of volcanic ash from Cotopaxi Volcano on the nutritional quality and biological traits of potato tubers (Solanum tuberosum L.) cultivated in the Cotopaxi region.
Raluca A. Mihai, Ramiro Fernando Vivanco Gonzaga, Nathaly Raquel Romero Balladares, Rodica D. Catana   +3 more
doaj   +1 more source

LSTM Neural Network Based Forecasting Model for Wheat Production in Pakistan

Agronomy, 2019
Pakistan’s economy is largely driven by agriculture, and wheat, mostly, stands out as its second most produced crop every year. On the other hand, the average consumption of wheat is steadily increasing as well, due to which its exports are not ...
Sajjad Ali Haider, Syed Rameez Naqvi, Tallha Akram, Gulfam Ahmad Umar, Aamir Shahzad, Muhammad Rafiq Sial, Shoaib Khaliq, Muhammad Kamran   +7 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Impact of Babaco (Vasoncelea x pentagona (Heilborn) Mabb.) Fruit Ripening Stages on Phytochemical Composition and Biological Properties

Metabolites
Background: This research article delves into Babaco fruit’s—an Ecuadorian product with immense nutraceutical potential phytochemical composition and biological activity—in different maturation fruit stages.
Raluca A. Mihai, Mauricio G. Canchignia Guacollantes, Ramiro F. Vivanco Gonzaga, Nelson S. Cubi-Insuaste, Rodica D. Catana   +4 more
doaj   +1 more source

Water balance for agriculture production in the dry seasons of the Mekong river delta in Vietnam

Vietnam Journal of Science, Technology and Engineering, 2022
Water is the most important component of agriculture production, especially during the dry seasons when all water sources are scarce yet water needs are very high.
Le Anh Tuan
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Assessment of phenolic composition and antioxidant activity of fermented Andean blackberry beverage enriched with medicinal plants of Ecuador

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
In recent years there has been a great interest in functional beverages with antioxidant capacity that impart various health implications upon consumption due to the presence of various bioactive components, like phenols.
Raluca A. MIHAI, Nicolas J. LOPEZ GUERRA, Rodica D. CATANA   +2 more
doaj   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source