Results 181 to 190 of about 3,737,571 (308)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion. [PDF]

EMBO J
Jiang M, Zhang J, He J, Miao Y, Wang L, Zhong H, Gong Y, Li Z, Du LL, Xu X, Chen C, Ydyrys A, Xia Y, Cao Q, Lou H, Hou W.   +15 more
europepmc   +1 more source

Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements. [PDF]

Nature, 2023
Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff SP, Zhang Z.   +10 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Influence of Post-Processing on S-Phase Formation During Plasma Nitriding of Additively Manufactured Inconel 939. [PDF]

Materials (Basel)
Maj P, Radziejewska J, Diduszko R, Marczak M, Nowicki R, Anna PL, Borowski T, Sitek R.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phase sensitive parametric mixers for coherent all-optical signal processing

We discuss the application of phase sensitive fiber optical parametric devices for the processing and quantization of optical phase including recent experimental ...
Slavík, R., Petropoulos, P., Richardson, D.J., Kakande, J.   +3 more
core  

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability. [PDF]

Mol Cell
Marmolejo CO, Sanchez C, Helms E, McEvoy MJ, Lee J, Werner M, Roberts P, Hamperl S, Saldivar JC.   +8 more
europepmc   +1 more source

Switching on S phase [PDF]

Nature Reviews Molecular Cell Biology, 2001
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source