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Roles for ORC in M Phase and S Phase
Science, 1998The origin recognition complex (ORC), a six-subunit protein, functions as the replication initiator in the yeast Saccharomyces cerevisiae . Initiation depends on the assembly of the prereplication complex in late M phase and activation in S phase. One subunit of ORC, Orc5p, was required at G 1
A, Dillin, J, Rine
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Science, 1989
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the last few years there have been major advances in understanding eukaryotic chromosome replication. Patterns of replication origins have been mapped accurately in yeast chromosomes.
Laskey, R. A. +2 more
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In each cell cycle the complex structure of the chromosome must be replicated accurately. In the last few years there have been major advances in understanding eukaryotic chromosome replication. Patterns of replication origins have been mapped accurately in yeast chromosomes.
Laskey, R. A. +2 more
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Perspectives on PARPs in S Phase
Trends in Genetics, 2019Accurate copying of DNA during S phase is essential for genome stability and cell viability. During genome duplication, the progression of the DNA replication machinery is challenged by limitations in nucleotide supply and physical barriers in the DNA template that include naturally occurring DNA lesions and secondary structures that are difficult to ...
Hana Hanzlikova, Keith W. Caldecott
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1998
The regulation of S phase can be divided into factors and activities that promote DNA replication at the G1-S boundary and those that prevent DNA replication once a segment of DNA has replicated. Considerable regulation is achieved by the synthesis of new proteins (and mRNA coding for these proteins) essential for DNA replication.
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The regulation of S phase can be divided into factors and activities that promote DNA replication at the G1-S boundary and those that prevent DNA replication once a segment of DNA has replicated. Considerable regulation is achieved by the synthesis of new proteins (and mRNA coding for these proteins) essential for DNA replication.
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Nuclear morphology during the S phase
Microscopy Research and Technique, 1998In order to evaluate at the ultrastructural level the chromatin arrangement during the S phase of the cell cycle, the detection of Bromodeoxyuridine (BrdU) by immunogold has been performed in synchronized 3T3 fibroblasts, regenerating liver, and Friend Leukemia Cells (FLC).
MAZZOTTI G +3 more
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Science's STKE, 2004
Cyclin E functions as the activating subunit of the cyclin-dependent kinase 2 complex, which regulates the initiation of DNA synthesis (S phase) in proliferating cells. However, the phenotypes of cyclin E knockout mice are not identical to those of Cdk2 knockout mice, and so cyclin E may have other functions independent of its interaction with Cdk2 ...
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Cyclin E functions as the activating subunit of the cyclin-dependent kinase 2 complex, which regulates the initiation of DNA synthesis (S phase) in proliferating cells. However, the phenotypes of cyclin E knockout mice are not identical to those of Cdk2 knockout mice, and so cyclin E may have other functions independent of its interaction with Cdk2 ...
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The temporal structure of S phase
Cell, 1975DNA synthesis in the S phase of V79 and CHO Chinese hamster cells was examined in detail using an automated system for selection and subculturing of mitotic cells and four different assays for DNA synthesis. Flow microfluorometric (FMF) analysis showed that the selected populations were highly synchronous with few noncycling cells. In CHO cells changes
Robert R. Klevecz +2 more
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2008
We present a calculation of eta/s for the meson gas (zero baryon number), with the viscosity computed within unitarized NLO chiral perturbation theory, and confirm the observation that eta/s decreases towards the possible phase transition to a quark-gluon plasma/liquid. The value is somewhat higher than previously estimated in LO chi PT.
Dobado, Antonio +2 more
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We present a calculation of eta/s for the meson gas (zero baryon number), with the viscosity computed within unitarized NLO chiral perturbation theory, and confirm the observation that eta/s decreases towards the possible phase transition to a quark-gluon plasma/liquid. The value is somewhat higher than previously estimated in LO chi PT.
Dobado, Antonio +2 more
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Varactor S-Band Direct Phase Modulator
IEEE Journal of Solid-State Circuits, 1966This paper describes the design technique and the test results for an S-band direct phase modulator with extremely linear phase characteristics. A modulation index of 2.4 radians (300/spl deg/ phase variation) with a phase distortion of less than 0.5 percent was obtained at 2.2 GHz. The modulator consisted of two cascaded stages, each stage employing a
C. Kim, J. Borer, C. Lee
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The S-phase cytotoxicity of camptothecin
Experimental Cell Research, 1991The DNA topoisomerase I inhibitor camptothecin (CAM) is selectively cytotoxic to S-phase cells of HL-60, and some other myelogenous leukemic lines. The early effects of cell exposure to 0.05-0.2 micrograms/ml CAM are seen after 2 h; at that time a progressive degradation of DNA in the chromatin of S-phase cells is initiated.
G, Del Bino +2 more
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