Results 51 to 60 of about 40,362 (222)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

The Role of the Oculomotor System in Updating Visual-Spatial Working Memory across Saccades. [PDF]

PLoS ONE, 2016
Visual-spatial working memory (VSWM) helps us to maintain and manipulate visual information in the absence of sensory input. It has been proposed that VSWM is an emergent property of the oculomotor system. In the present study we investigated the role of
Paul J Boon, Artem V Belopolsky, Jan Theeuwes   +2 more
doaj   +1 more source

Unmasking saccadic uncrowding

Vision Research, 2016
Stimuli that are briefly presented around the time of saccades are often perceived with spatiotemporal distortions. These distortions do not always have deleterious effects on the visibility and identification of a stimulus. Recent studies reported that when a stimulus is the target of an intended saccade, it is released from both masking and crowding.
Ağaoğlu, Mehmet N, Öğmen, Haluk, Chung, Susana TL   +2 more
openaire   +4 more sources

Evaluation of Experienced Manipulation Characteristics in Robotic Surgery Using Log Data From the Hinotori Surgical System

Annals of Gastroenterological Surgery, EarlyView.
This study analyzed log data from the Japanese hinotori surgical robot to characterize manipulation performed by experienced surgeons in robotic surgery. Compared with less‐experienced surgeons, the experienced group demonstrated shorter task durations, reduced travel distances with the right instrument (Arm3), faster and more dynamically modulated ...
Masaki Saito, Shunsuke Hayakawa, Hiroyuki Sagawa, Tamiaki Kondo, Masanao Ohashi, Sunao Ito, Reo Sato, Hajime Ushigome, Kenta Saito, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi   +11 more
wiley   +1 more source

Saccades in children

Vision Research, 2006
Saccades are necessary for optimal vision. Little is known about saccades in children. We recorded saccades using an infrared eye tracker in 39 children, aged 8-19 years. Participants made saccades to visual targets that stepped 10 degrees or 15 degrees horizontally and 5 degrees or 10 degrees vertically at unpredictable time intervals.
Salman, Michael S., Sharpe, James A., Eizenman, Moshe, Lillakas, Linda, Westall, Carol, To, Teresa, Dennis, Maureen, Steinbach, Martin J.   +7 more
openaire   +2 more sources

Post-saccadic changes disrupt attended pre-saccadic object memory

Journal of Vision, 2021
Trans-saccadic memory consists of keeping track of objects' locations and features across saccades; pre-saccadic information is remembered and compared with post-saccadic information. It has been shown to have limited resources and involve attention with respect to the selection of objects and features.
Laurin, Anne-Sophie, Bleau, Maxime, Gedjakouchian, Jessica, Fournet, Romain, Pisella, Laure, Khan, Aarlenne Zein   +5 more
openaire   +3 more sources

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis

Frontiers in Integrative Neuroscience, 2023
BackgroundAltered patterns of eye-movements during scene exploration, and atypical gaze preferences in social settings, have long been noted as features of the Autism phenotype. While these are typically attributed to differences in social engagement and
Katy Tarrit, Katy Tarrit, Edward G. Freedman, Ana A. Francisco, Douwe J. Horsthuis, Sophie Molholm, Sophie Molholm, John J. Foxe, John J. Foxe   +8 more
doaj   +1 more source

Global saccadic adaptation

Vision Research, 2010
Our actions need constant calibration to arrive accurately at locations of their intended goals; errors in execution must drive rapid adjustments. As an example, saccadic eye movements are vital for bringing objects of interest into the high-acuity center of vision and they must be continually tuned to compensate for ongoing changes in body, muscle ...
Rolfs, M., Knapen, T., Cavanagh, P.
openaire   +3 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source