Results 51 to 60 of about 79,953 (394)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]

, 2018
This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R, Lee, Keunsook, Mukaremera, Liliane, Nielsen, Kirsten, Wagener, Jeanette, Wiesner, D. L.   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Gastrointestinal exposure to silica nanoparticles induced Alzheimer’s disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC

Journal of Nanobiotechnology
Background Silica nanoparticles (SiO2 NPs) are widely used in the food and pharmaceutical industries and dramatically increase the health risks associated with gastrointestinal exposure.
Lisha Du, Benjie Wang, Xinyi Wang, Longxing Wang, Renjun Wang, Yuanyuan Zhang, Zemei Hong, Xiaofei Han, Yadong Wang   +8 more
doaj   +1 more source

Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface

Sensors, 2007
We designed and synthesized phenylboronic acid as a molecular recognitionmodel system for saccharide detection. The phenylboronic acid derivatives that haveboronic acid moiety are well known to interact with saccharides in aqueous solution; thus,they can
Kwangnak Koh, Won Gun An, Yoon-Hwae Hwang, Yeong-Soon Gal, Jae-Ho Kim, Jaebeom Lee, Minsu Lee, Hongxia Chen   +7 more
doaj   +1 more source

Naturally Derived Silicone Surfactants Based on Saccharides and Cysteamine

Molecules, 2021
Silicone surfactants are widely used in many industries and mostly rely on poly(ethylene glycol) (PEG) as the hydrophile. This can be disadvantageous because commercial PEG examples vary significantly in polydispersity—constraining control over surface ...
Adrien Lusterio, Michael A. Brook
doaj   +1 more source

Mutations in \u3cem\u3eRhizobium phaseoli\u3c/em\u3e that Lead to Arrested Development of Infection Threads [PDF]

, 1986
Two Rhizobium phaseoli mutants, isolated previously by Tn5 mutagenesis, elicited infection threads which ceased development prematurely, usually within root hairs. These infection threads were wide, globular, and otherwise altered in morphology, compared
Kulpaca, Bruce, Noel, K. Dale, Vandenbosch, Kathryn A.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Particle Design of Cellulose and the Other Excipients for a Directly Compressible Filler-Binder

KONA Powder and Particle Journal, 2014
Cellulose and saccharide are commonly used filler-binder. This summary refers to the technology for high performance filler-binder of direct compression, using these two materials. In case of saccharide filler-binder,
Hiroto Miyamoto
doaj   +1 more source

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source