Results 311 to 320 of about 496,628 (371)

Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress

open access: yesThe FEBS Journal, EarlyView.
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge   +7 more
wiley   +1 more source

Versatile roles of disordered transcription factor effector domains in transcriptional regulation

open access: yesThe FEBS Journal, EarlyView.
Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta   +3 more
wiley   +1 more source

When the host senses the microbiota's metabolism – the interplay between food and microbiota in C. elegans

open access: yesThe FEBS Journal, EarlyView.
The microbiota plays a major role in metazoan physiology, particularly in the intestinal tract. Nonetheless, its extreme complexity hinders functional studies. Taking advantage of the Caenorhabditis elegans and Escherichia coli model systems, Feng et al. report the physiological effect of purine biosynthesis deficiencies in E.
José Eduardo Gomes
wiley   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

open access: yesThe FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres   +10 more
wiley   +1 more source

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