Transcription Regulatory Protein <i>SIN3</i> (YOL004W) Influences Mutation Rates in <i>Saccharomyces cerevisiae</i>. [PDF]
Eftimie A, Meyer D.
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Comparative analysis of physicochemical properties, antioxidant activities, and metabolomic profiles in daylily-supplemented craft beer fermented with different <i>Saccharomyces</i> strains. [PDF]
Mu Y+5 more
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Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge+7 more
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Effect of Saccharomyces boulardii supplementation to bismuth quadruple therapy on Helicobacter pylori eradication. [PDF]
Jiang YZ, Ma K, Cui C, Li ZY, Wang XY.
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Versatile roles of disordered transcription factor effector domains in transcriptional regulation
Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta+3 more
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Horizontal Transfer and Recombination Fuel Ty4 Retrotransposon Evolution in Saccharomyces. [PDF]
Chen J, Garfinkel DJ, Bergman CM.
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The microbiota plays a major role in metazoan physiology, particularly in the intestinal tract. Nonetheless, its extreme complexity hinders functional studies. Taking advantage of the Caenorhabditis elegans and Escherichia coli model systems, Feng et al. report the physiological effect of purine biosynthesis deficiencies in E.
José Eduardo Gomes
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Rising Into Relevance: A Rare Case of <i>Saccharomyces cerevisiae</i> Pyelonephritis in an Immunosuppressed Patient With Exposure to Sourdough Starter. [PDF]
Mingo A+3 more
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Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres+10 more
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