Results 331 to 340 of about 632,478 (413)

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

open access: yesThe FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika   +7 more
wiley   +1 more source

Melatonin-protein interactions are dependent on yeast carbon metabolism. [PDF]

open access: yesSci Rep
Morcillo-Parra MA   +5 more
europepmc   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

open access: yesThe FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher   +3 more
wiley   +1 more source

New insights into Sti1/Hop's cochaperone function highlight the complexity of proteostatic regulation

open access: yesThe FEBS Journal, EarlyView.
Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch   +1 more
wiley   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

open access: yesThe FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány   +6 more
wiley   +1 more source

Typing of clinical and reference strains of Saccharomyces cerevisiae using pulsed-field gel electrophoresis and MALDI-TOF MS. [PDF]

open access: yesSci Rep
Cieślik J   +7 more
europepmc   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

open access: yesThe FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka   +3 more
wiley   +1 more source

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