Results 331 to 340 of about 632,478 (413)
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika+7 more
wiley +1 more source
Melatonin-protein interactions are dependent on yeast carbon metabolism. [PDF]
Morcillo-Parra MA+5 more
europepmc +1 more source
Transcription‐coupled repair: tangled up in convoluted repair
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher+3 more
wiley +1 more source
Cheilitis Granulomatosa: A Case Report of a Sarcoid Mimic. [PDF]
Nagy S, Fraser M, Kesselman MM.
europepmc +1 more source
Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch+1 more
wiley +1 more source
Supplementation with Potato Protein Concentrate and <i>Saccharomyces boulardii</i> to an Antibiotic-Free Diet Improves Intestinal Health in Weaned Piglets. [PDF]
Reis de Souza TC+5 more
europepmc +1 more source
Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány+6 more
wiley +1 more source
Typing of clinical and reference strains of Saccharomyces cerevisiae using pulsed-field gel electrophoresis and MALDI-TOF MS. [PDF]
Cieślik J+7 more
europepmc +1 more source
A guide to heat shock factors as multifunctional transcriptional regulators
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka+3 more
wiley +1 more source