Results 11 to 20 of about 2,948 (142)

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei. [PDF]

Dev Dyn
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Lee JH, Yamoah EN, Kersigo J, Elliott K, LaRoda N, Pavlinkova G, Fritzsch B.   +6 more
europepmc   +2 more sources

Comparative Cochlear-Vestibular Aging Reveals Age-Aligned Mitochondrial Ultrastructural Burden, Mitophagy-Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline. [PDF]

Aging Cell
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Xie J, Zhang X, Tian J, Yan Y, Shi K, Pan Y, Zhang Y, Chen Z, Sun J, Lv H, Chen J, Ren X, Kamogashira T, Zhang X, Gao Y.   +14 more
europepmc   +2 more sources

Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells

Neural Plasticity, 2021
As part of the inner ear, the vestibular system is responsible for sense of balance, which consists of three semicircular canals, the utricle, and the saccule.
Di Deng, Xiaoqing Qian, Binjun Chen, Xiaoyu Yang, Yanmei Wang, Fanglu Chi, Yibo Huang, Yu Zhao, Dongdong Ren   +8 more
doaj   +1 more source

Case Report: Isolated Idiopathic Saccular Dysfunction

Frontiers in Neurology, 2021
Advances in vestibular testing have now allowed us to test each semicircular canal as well as the utricle and saccule, independently. This has led to the discovery of new patterns of vestibular dysfunction that were once impossible to evaluate.
Sofia Waissbluth, Javier Oyarzún
doaj   +1 more source

Developmental Expression of Membrane Pumps and Ion Channels in Human Vestibular Endolymph Homeostasis. [PDF]

Dev Neurobiol
ABSTRACT The expression patterns of key membrane pumps and ion channels involved in endolymph cycling have been studied in the rodent inner ear and the developing and adult human cochlea. However, little is known about their expression during the development of the human vestibular system.
van Beelen ESA, van der Valk WH, de Groot JCMJ, van Benthem PPG, Locher H.   +4 more
europepmc   +2 more sources

Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. [PDF]

PLoS ONE, 2011
Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(-/-), are associated with an enlargement and acidification of the membranous ...
Hyoung-Mi Kim, Philine Wangemann
doaj   +1 more source

A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System: Is Meniere's Disease Caused by an Acute Endolymph Backflow?

Frontiers in Surgery, 2021
Background: The etiology of Meniere's disease (MD) and endolymphatic hydrops believed to underlie its symptoms remain unknown. One reason may be the exceptional complexity of the human inner ear, its vulnerability, and surrounding hard bone.
Hao Li, Gunesh P. Rajan, Gunesh P. Rajan, Jeremy Shaw, Seyed Alireza Rohani, Hanif M. Ladak, Sumit Agrawal, Helge Rask-Andersen   +7 more
doaj   +1 more source

Advances in otolith-related protein research

Frontiers in Neuroscience, 2022
Otoliths are biological crystals formed by a layer of calcium carbonate crystal that adhere to the ciliary surface of the utricular and saccular receptors in the vestibule of all vertebrates inner ear, enabling the utricle and saccule to better perceive ...
Shouju Huang, Shouju Huang, Shuxia Qian
doaj   +1 more source

Morphological analysis of the vestibular system of guinea pigs poisoned by organophosphate

Brazilian Journal of Otorhinolaryngology, 2016
INTRODUCTION: The vestibular system is responsible for body balance. There are substances that damage it, causing dizziness; these are termed vestibulotoxic substances.
Lícia Assunção Cogo, Valdete Alves Valentins dos Santos Filha, Adriana de Andrade Batista Murashima, Miguel Angelo Hyppolito, Aron Ferreira da Silveira   +4 more
doaj   +1 more source

Quantitative assessment of inner ear variation in elasmobranchs

Scientific Reports, 2023
Considerable diversity has been documented in most sensory systems of elasmobranchs (sharks, rays, and skates); however, relatively little is known about morphological variation in the auditory system of these fishes.
Derek J. Sauer, Craig A. Radford, Christopher G. Mull, Kara E. Yopak   +3 more
doaj   +1 more source