The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei. [PDF]
Dev DynBACKGROUND Knockin mouse models expressing calbindin (Calb1), calretinin (Calb2), and peripherin (Prph) exhibit changes in hair cells (HCs), spiral ganglion neurons (SGN), vestibular ganglion neurons (VGNs), and their central projections.
Lee JH +6 more
europepmc +3 more sources
Developmental Expression of Membrane Pumps and Ion Channels in Human Vestibular Endolymph Homeostasis. [PDF]
Dev NeurobiolABSTRACT The expression patterns of key membrane pumps and ion channels involved in endolymph cycling have been studied in the rodent inner ear and the developing and adult human cochlea. However, little is known about their expression during the development of the human vestibular system.
van Beelen ESA +4 more
europepmc +2 more sources
Annals of Anatomy, 2023 BACKGROUND The aqeductus vestibuli (aqueduct) is believed to connect to the saccule in embryos and adults. However, in embryos, the saccule and utricle are known to communicate widely to provide a common endolymph space "atrium". METHODS Using sagittal
Yohei Honkura +6 more
semanticscholar +1 more source
Frontiers in Surgery, 2021 Background: The etiology of Meniere's disease (MD) and endolymphatic hydrops believed to underlie its symptoms remain unknown. One reason may be the exceptional complexity of the human inner ear, its vulnerability, and surrounding hard bone.
Hao Li +7 more
doaj +1 more source
Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. [PDF]
PLoS ONE, 2011 Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(-/-), are associated with an enlargement and acidification of the membranous ...
Hyoung-Mi Kim, Philine Wangemann
doaj +1 more source
Advances in otolith-related protein research
Frontiers in Neuroscience, 2022 Otoliths are biological crystals formed by a layer of calcium carbonate crystal that adhere to the ciliary surface of the utricular and saccular receptors in the vestibule of all vertebrates inner ear, enabling the utricle and saccule to better perceive ...
Shouju Huang, Shouju Huang, Shuxia Qian
doaj +1 more source
Quantitative assessment of inner ear variation in elasmobranchs
Scientific Reports, 2023 Considerable diversity has been documented in most sensory systems of elasmobranchs (sharks, rays, and skates); however, relatively little is known about morphological variation in the auditory system of these fishes.
Derek J. Sauer +3 more
doaj +1 more source
Otopathologic Patterns of Cellular Degeneration in the Peripheral Vestibular Organ Secondary to Head Trauma. [PDF]
LaryngoscopeThis study examines vestibular degeneration following head trauma, comparing cases with and without fractures. Histopathological analysis of 26 temporal bones showed more severe damage in nonfracture cases, particularly in Scarpa's ganglion cells and vestibular hair cells.
Shimura T +6 more
europepmc +2 more sources
Morphological analysis of the vestibular system of guinea pigs poisoned by organophosphate
Brazilian Journal of Otorhinolaryngology, 2016 INTRODUCTION: The vestibular system is responsible for body balance. There are substances that damage it, causing dizziness; these are termed vestibulotoxic substances.
Lícia Assunção Cogo +4 more
doaj +1 more source
Inner ear morphology in the Atlantic molly Poecilia mexicana [PDF]
, 2011 Fishes show an amazing diversity in hearing abilities, inner ear structures, and otolith morphology. Inner ear morphology, however, has not yet been investigated in detail in any member of the diverse order Cyprinodontiformes.
Hess, Martin +2 more
core +1 more source