Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. [PDF]
, 2013 BACKGROUND: Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) is caused by a 1.5-3 Mb microdeletion of chromosome 22q11.2, frequently referred to as 22q11.2 deletion syndrome (22q11DS).
Baldini, Antonio +4 more
core +1 more source
Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants [PDF]
, 2008 Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ).
Andreescu +57 more
core +1 more source
Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
, 2019 Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L. +8 more
core +1 more source
Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. [PDF]
, 2001 The mammalian inner ear contains two sensory organs, the cochlea and vestibule. Their sensory neuroepithelia are characterized by a mosaic of hair cells and supporting cells.
Aubert, A. +6 more
core +2 more sources
The Growing Evidence for the Importance of the Otoliths in Spatial Memory
Frontiers in Neural Circuits, 2019 Many studies have demonstrated that vestibular sensory input is important for spatial learning and memory. However, it has been unclear what contributions the different parts of the vestibular system – the semi-circular canals and otoliths – make to ...
Paul F. Smith +2 more
doaj +1 more source
Association between hearing loss and vestibular disorders : a review of the interference of hearing in the balance [PDF]
, 2015 Dizziness is very prevalent and makes a great impact on people’s life. Because of anatomical and functional similarities of hearing and vestibular systems, it is noted that there is a big relation between hearing loss and vestibular disorders.
Sampaio, André Luiz Lopes +2 more
core +1 more source
Membrane Stress in the Human Labyrinth and Meniere Disease: A Model Analysis
International Archives of Otorhinolaryngology, 2015 Introduction The nature and extent of membrane damage encountered in Meniere disease remains unexplained. Pressure-induced membrane stress may underlie the characteristic hydropic distention.
Daniel J. Pender
doaj +1 more source
Early assessment of vestibular function after unilateral cochlear implant surgery [PDF]
, 2019 Introduction : Cochlear implantation (CI) has been reported to negatively effect on the vestibular function. The study of the vestibular function has variably been conducted by different types of diagnostic tools. The combined use of modern, rapidly
Barbara, M +6 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Frontiers in NeurologyIntroductionCochlear implantation is currently regarded as a safe and minimally invasive procedure. However, cochlear implantation can have an impact on vestibular function, despite the lack of correlation between patient symptomatology and damage in ...
Raquel Manrique-Huarte +3 more
doaj +1 more source