Results 41 to 50 of about 6,604 (174)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Increased prevalence of pelvic venous congestion sign on sacroiliac MRI in women with clinically suspected sacroiliitis

İstanbul Kuzey Klinikleri, 2020
OBJECTIVE: To compare the prevalence of pelvic venous congestion (PVC) sign on sacroiliac and hip MRI in women of reproductive age as a possible cause of pain mimicking sacroiliitis.
Ahmet Peker, Gozde Tokatli, Ali Balci, Isil Basara Akın, Canan Altay, Gercek Can   +5 more
doaj   +1 more source

Artificial intelligence for the detection of sacroiliitis on magnetic resonance imaging in patients with axial spondyloarthritis

Frontiers in Immunology, 2023
BackgroundMagnetic resonance imaging (MRI) is important for the early detection of axial spondyloarthritis (axSpA). We developed an artificial intelligence (AI) model for detecting sacroiliitis in patients with axSpA using MRI.MethodsThis study included ...
Seulkee Lee, Uju Jeon, Ji Hyun Lee, Seonyoung Kang, Hyungjin Kim, Jaejoon Lee, Myung Jin Chung, Myung Jin Chung, Hoon-Suk Cha   +8 more
doaj   +1 more source

Biportal Endoscopic Posterior Open‐Window Focal Debridement and Lavage for Sacroiliac Joint Tuberculosis

Arthroscopy Techniques, EarlyView.
Abstract Sacroiliac joint tuberculosis (SJT), although relatively uncommon, may lead to severe destruction and functional impairment of the sacroiliac joint. Surgical intervention is recommended for patients with significant joint destruction, mild cystic changes, or sacroiliac joint instability. Early bone fusion may be facilitated through drainage of
Wei Cheng, Wei Zhang, Hao Pan, Gaoyong Jia   +3 more
wiley   +1 more source

The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Infantile‐onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very‐early‐onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited.
Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram   +2 more
wiley   +1 more source

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

Preliminary Validation of the Early Sacroiliitis Screening Tool (ESHST) for Identifying Hidradenitis Suppurativa Patients at High Risk of Spondyloarthritis

International Journal of Dermatology, EarlyView.
Development and preliminary validation of the Early Sacroiliitis Screening Tool (ESHST), a dermatology‐oriented screening questionnaire for identifying hidradenitis suppurativa patients at increased risk of spondyloarthritis. ABSTRACT Background Hidradenitis suppurativa (HS) is increasingly recognized as a systemic inflammatory disease associated with ...
Umut Bakay, Ozge Sevil Karstarli Bakay, Tugba Izci Duran, Niyazi Cetin   +3 more
wiley   +1 more source

Diagnostic Value of MRI of the Sacroiliac Joints in Juvenile Spondyloarthritis

Journal of the Belgian Society of Radiology, 2016
Early diagnosis of spondyloarthritis (SpA) is becoming more important as new medical treatment options have become available to treat inflammation and delay progression of the disease.
Nele Herregods, Joke Dehoorne, Jacob Jaremko, Rik Joos, Xenofon Baraliakos, Koenraad Verstraete, Lennart Jans   +6 more
doaj   +1 more source

Measuring the Impact: Magnetic Resonance Imaging Response of Sacroiliac Joints to Tumor Necrosis Factor Inhibitors in Youth With Axial Disease

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1527-1534, July 2026.
Objective To evaluate the timeline for resolution of sacroiliac joint (SIJ) inflammation, changes in structural lesions, and their correlation with patient‐reported outcomes (PROs) in youth with axial juvenile spondyloarthritis (axJSpA) initiating tumor necrosis factor inhibitor (TNFi).
Timothy G. Brandon, Rui Xiao, Daniel J. Lovell, Edward Oberle, Matthew L. Stoll, Nancy A. Chauvin, Michael L. Francavilla, Walter P. Maksymowych, Pamela F. Weiss   +8 more
wiley   +1 more source

Sacroliliitis as Debut of Crohn’s Disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to present a clinical case of a patient with sacroiliitis preceding the development of the typical clinical picture of Crohn’s disease with colonic involvement.Key points.
E. A. Poluektova, A. I. Ulyanin, M. S. Shek, O. S. Shifrin, V. T. Ivashkin   +4 more
doaj   +1 more source