Results 71 to 80 of about 262,483 (141)

En 2018, SADS-CoV et PEDV, une répétition avant Sars-CoV-2 ? [PDF]

Option/Bio, 2022
europepmc   +2 more sources

Bile acids (BAs) promote SADS-CoV replication and affect the early stage of viral infection in PIEs.

, 2022
(A) Schematic illustration of BA treatment in SADS-CoV-GFP infection. The image was created using the website https://app.biorender.com/. (B) Ileal PIE monolayers were inoculated with SADS-CoV-GFP at MOI = 0.1 alone or simultaneously with BAs for 48 h at
Chan Ding (317445), Yao-Wei Huang (426136), Shu Jeffrey Zhu (12867687), Yi-Xin Tang (12867684), Pan Qin (6517490), Qi-Yue Yang (12867681), Shu-Xian Chen (10719084), Jin-Yan Xie (9920614), Yong-Le Yang (10977618), Gan Wang (786657)   +9 more
core   +1 more source

A balance between stability and flexibility: Adaptive patterns of self‐regulated learning processes shape game‐based learning

British Journal of Educational Technology, EarlyView.
Abstract To ensure learning efficiency in game‐based learning (GBL), learners must regulate cognitive, affective, metacognitive and motivational (CAMM) processes, collectively known as self‐regulated learning (SRL). SRL is dynamic and non‐linear, characterized by regulatory patterns and CAMM interactions that lead to macro‐level SRL behaviours. In this
Elizabeth B. Cloude, Stefan E. Huber, Jingwei Wei, Bianca Esmanhoto, Muhterem Dindar, Manuel Ninaus, Kristian Kiili   +6 more
wiley   +1 more source

Bile acids (BAs) enhance SADS-CoV replication in a virus-specific and cell-specific manner.

, 2022
(A) Cytotoxic effect of different BAs in PIEs at the indicated concentration. (B) PIE monolayers were infected with PEDV at MOI = 1 in the presence of BAs for 24 h. Viral titer was determined by qRT-PCR.
Chan Ding (317445), Yao-Wei Huang (426136), Shu Jeffrey Zhu (12867687), Yi-Xin Tang (12867684), Pan Qin (6517490), Qi-Yue Yang (12867681), Shu-Xian Chen (10719084), Jin-Yan Xie (9920614), Yong-Le Yang (10977618), Gan Wang (786657)   +9 more
core   +1 more source

Treatment plan quality comparison between ZAP‐Axon® Krylov optimizer and Leksell Gamma Knife® Lightning optimizer for brain metastasis

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Purpose This study compares stereotactic radiosurgery (SRS) treatment plan quality between the recently launched ZAP‐Axon® Krylov optimizer and the Leksell Gamma Knife® (LGK) Lightning optimizer for brain metastasis (BM). Methods Thirty (n = 30) patients who were previously treated with LGK SRS or fractionated SRS were selected and divided ...
Yongsook C. Lee, Alexander Maslowski, Rupesh Kotecha, Ranjini Tolakanahalli, D Jay Wieczorek, Matthew D. Hall, Minesh P. Mehta, Michael W. McDermott, Alonso N. Gutierrez   +8 more
wiley   +1 more source

SADS-CoV nsp1 inhibits the STAT1 phosphorylation by promoting K11/K48-linked polyubiquitination of JAK1 and blocks the STAT1 acetylation by degrading CBP. [PDF]

J Biol Chem
The newly discovered zoonotic coronavirus swine acute diarrhea syndrome coronavirus (SADS-CoV) causes acute diarrhea, vomiting, dehydration, and high mortality rates in newborn piglets. Although SADS-CoV uses different strategies to evade the host's innate immune system, the specific mechanism(s) by which it blocks the interferon (IFN) response remains
Xiang Y, Mou C, Zhu L, Wang Z, Shi K, Bao W, Li J, Chen X, Chen Z.   +8 more
europepmc   +3 more sources

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, Volume 115, Issue 11, Page 2421-2426, November 2026.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

Development and Clinical Applications of a 5-Plex Real-Time RT-PCR for Swine Enteric Coronaviruses

Viruses, 2022
A PEDV/PDCoV/TGEV/SADS-CoV/XIPC 5-plex real-time RT-PCR was developed and validated for the simultaneous detection and differentiation of four swine enteric coronaviruses (PEDV, PDCoV, TGEV and SADS-CoV) in one PCR reaction (XIPC serves as an exogenous ...
Jin-Hui Zhu, Gaurav Rawal, Ethan Aljets, Wannarat Yim-Im, Yong-Le Yang, Yao-Wei Huang, Karen Krueger, Phillip Gauger, Rodger Main, Jianqiang Zhang   +9 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, Volume 13, Issue 59, 23 October 2026.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of EGT710, a Novel Coronavirus Mpro Inhibitor, in Healthy Adults: A Randomized, Single‐ and Multiple‐Dose Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 10, October 2026.
Abstract Antiviral therapy is needed to address acute coronavirus disease. EGT710 is a novel low‐molecular‐weight inhibitor of the coronavirus main protease (Mpro). This first‐in‐human study evaluated the safety, tolerability, and pharmacokinetics of EGT710 in healthy adults.
Jart A. F. Oosterhaven, Jonathan Trolander, Lidiya Bebrevska, Hilmar Schiller, Begum Alaybeyoglu, Suzanne Gaudet, Allison Claas, Kamal Kumar Balavenkatraman, Renee Bergeron, Fernanda V. Duraes, Frederique Chaperon, Swati Ghanshani, Elisabete Goncalves, Steven J. Kovacs   +13 more
wiley   +1 more source