Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Welcome to the first issue of Patient Safety! Brought to you by the Patient Safety Authority, an independent agency of the Commonwealth of Pennsylvania, this brand-new journal is unlike any other you’ve seen. Since patients are at the heart of everything
Patient Safety Authority
doaj +1 more source
Conclusion on the peer review of the pesticide risk assessment of confirmatory data submitted for the active substance ethoprophos [PDF]
The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessment carried out by the competent authority of the rapporteur Member State the United Kingdom, for the pesticide active substance ethoprophos
European Food Safety Authority
doaj +1 more source
Fire design in safety engineering: likely fire curve for people’s safety [PDF]
The present study analyses fire design settings according to Fire Safety Engineering (FSE) for the simulation of fire in civil activities and compares these simulations developed using natural and analytic fire curves.
Grossi, Luca +4 more
core +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reasoned opinion on the review of the existing maximum residue levels (MRLs) for fluoxastrobin according to Article 12 of Regulation (EC) No 396/2005 [PDF]
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance fluoxastrobin.
European Food Safety Authority
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Acknowledgement to Reviewers of Safety in 2018
Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Safety Editorial Office
doaj +1 more source
Reasoned opinion on the review of the existing maximum residue levels (MRLs) for propargite according to Article 12 of Regulation (EC) No 396/2005 [PDF]
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance propargite.
European Food Safety Authority
doaj +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source

