Results 51 to 60 of about 10,375,512 (398)

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.

New England Journal of Medicine, 2002
BACKGROUND Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of gastrointestinal stromal tumors. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical
G. Demetri, M. von Mehren, C. Blanke, A. D. Van den Abbeele, B. Eisenberg, P. Roberts, M. Heinrich, D. Tuveson, S. Singer, M. Janicek, J. Fletcher, S. Silverman, S. Silberman, R. Capdeville, B. Kiese, B. Peng, S. Dimitrijević, B. Druker, C. Corless, C. Fletcher, H. Joensuu   +20 more
semanticscholar   +1 more source

RELATIONSHIP BETWEEN SAFETY CULTURE AND THE SAFETY CLIMATE, SAFETY BEHAVIOR AND SAFETY MANAGEMENT

Majalah Ilmiah Pengkajian Industri, 2023
This article aims to measure the application of occupational safety and health using Cooper's Reciprocal Safety Culture Model and Confirmatory Factor Analysis method.  The objective function of this article is to find out the aspects of safety culture that have been implemented by companies.
Restuputri, Dian Palupi, Giraldi, M Syahban, Kusuma Dewi, Shanty, Masudin, Ilyas, Yuliati, Uci   +4 more
openaire   +3 more sources

Special Issue: Pharmacy Education and Practice -Print Issue

Patient Safety, 2021
In celebration of National Pharmacist Day, recognizing the importance of pharmacists and their crucial role in our health and well-being, today we are publishing a special issue of _Patient Safety_ dedicated to pharmacy education and practice.
Patient Safety Authority
doaj   +1 more source

Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma.
M. Castro, J. Corren, I. Pavord, J. Maspero, S. Wenzel, K. Rabe, W. Busse, L. Ford, L. Sher, M. Fitzgerald, C. Katelaris, Y. Tohda, Bingzhi Zhang, H. Staudinger, G. Pirozzi, N. Amin, M. Ruddy, B. Akinlade, A. Khan, J. Chao, R. Martincova, N. Graham, J. Hamilton, B. Swanson, N. Stahl, G. Yancopoulos, A. Teper   +26 more
semanticscholar   +1 more source

Food safety risks [PDF]

, 2019
Foodborne diseases are responsible for 420,000 deaths each year, one-third of them in Africa. Food safety issues are usually attributed to traditional food systems, but the development of modern food systems in low-income (LI) and lower middle-income ...
Figuié, Muriel
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The REporting of A Disproportionality Analysis for DrUg Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Explanation and Elaboration

Drug Safety
In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect safety signals. Unfortunately, publishing disproportionality analyses lacks specific guidelines, often leading to incomplete and ambiguous
M. Fusaroli, Francesco Salvo, Bernard Bégaud, T. Alshammari, Andrew Bate, V. Battini, Andreas Brueckner, G. Candore, Carla Carnovale, Salvatore Crisafulli, P. Cutroneo, Charles Dolladille, M. Drici, J. Faillie, Adam Goldman, M. Hauben, M. T. Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G. N. Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, E. Poluzzi, Myriam Salem, D. Sartori, Nhung T H Trinh, Marco Tuccori, Florence van Hunsel, E. V. van Puijenbroek, Emanuel Raschi, Charles Khouri   +33 more
semanticscholar   +1 more source

Recommended Practices: Protecting Temporary Workers [PDF]

, 2014
[Excerpt] Workers employed through staffing agencies are generally called temporary or supplied workers. For the purposes of these recommended practices, “temporary workers” are those supplied to a host employer and paid by a staffing agency, whether or ...
National Institute for Occupational Safety and Health
core   +1 more source

Supporting the automated generation of modular product line safety cases [PDF]

, 2015
The effective reuse of design assets in safety-critical Software Product Lines (SPL) would require the reuse of safety analyses of those assets in the variant contexts of certification of products derived from the SPL.
Braga, Rosana T.V., de Oliveira, André L., Habli, Ibrahim, Kelly, Tim, Masiero, Paulo C., Papadopoulos, Yiannis   +5 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source