Results 61 to 70 of about 10,375,512 (398)
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
New England Journal of Medicine, 2013 BACKGROUND The programmed death 1 (PD-1) receptor is a negative regulator of T-cell effector mechanisms that limits immune responses against cancer. We tested the anti-PD-1 antibody lambrolizumab (previously known as MK-3475) in patients with advanced ...
O. Hamid +25 more
semanticscholar +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Determination of Safety Indicators in the Developed Muffins with Non-traditional Raw Materials [PDF]
, 2019 The aim of research is studying the effect of unconventional raw materials (buckwheat, oatmeal, rye, corn, milk whey, skimmed milk powder, propolis, flower pollen, bean powder, sesame oil, pumpkin seed oil, walnut oil, walnut kernels, candied fruit mixes
Bodak, M. (Mykhailo) +8 more
core
, 2007 Asymptotic safety is a set of conditions, based on the existence of a nontrivial fixed point for the renormalization group flow, which would make a quantum field theory consistent up to arbitrarily high energies. After introducing the basic ideas of this
Percacci, R.
core +3 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.
New England Journal of Medicine, 2015 BACKGROUND Alirocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), has been shown to reduce low-density lipoprotein (LDL) cholesterol levels in patients who are receiving statin therapy.
Jennifer G. Robinson +15 more
semanticscholar +1 more source
Safety management practices in the Malaysia Technical And Vocational Education Training (TVET) [PDF]
, 2021 For many years, the value of safety management practice has been the subject of research attention in many sectors in Malaysia in order to achieve a positive workplace safety climate.
Paimin, Aini Nazura +2 more
core
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Conclusion on the peer review of the pesticide risk assessment of the active substance <em>Spodoptera littoralis</em> nucleopolyhedrovirus [PDF]
EFSA Journal, 2012 <p>The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Estonia, for the pesticide active substance <em> ...
European Food Safety Authority
doaj +1 more source
Int. J. Soc. Robotics, 2009 This study emphasizes the need for standardized measurement tools for human robot interaction (HRI). If we are to make progress in this field then we must be able to compare the results from different studies.
C. Bartneck +3 more
semanticscholar +1 more source