Results 61 to 70 of about 5,613,091 (316)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Reporting of a Disproportionality Analysis for Drug Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Development and Statement

Drug Safety
Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their methods and results are generally poorly reported in published
M. Fusaroli, Francesco Salvo, Bernard Bégaud, T. Alshammari, Andrew Bate, V. Battini, Andreas Brueckner, G. Candore, Carla Carnovale, Salvatore Crisafulli, P. Cutroneo, Charles Dolladille, M. Drici, J. Faillie, Adam Goldman, M. Hauben, M. T. Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G. N. Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, E. Poluzzi, Myriam Salem, D. Sartori, N. T. Trinh, Marco Tuccori, Florence van Hunsel, E. V. van Puijenbroek, Emanuel Raschi, C. Khouri   +33 more
semanticscholar   +1 more source

Food Safety

Analytical Sciences, 2019
Food Safety is a key component of global challenges to both health and resources and is becoming increasingly complex given the global dimensions of food supply, the need to reduce food waste, and the growing importance of the efficient use of natural ...
H. Shiigi
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Food Security, Safety, and Sustainability—Getting the Trade-Offs Right [PDF]

, 2020
Ivar Vågsholm, Naser Shah Arzoomand, Sofia Boqvist   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Making food systems more resilient to food safety risks by including artificial intelligence, big data, and internet of things into food safety early warning and emerging risk identification tools.

Comprehensive Reviews in Food Science and Food Safety
To enhance the resilience of food systems to food safety risks, it is vitally important for national authorities and international organizations to be able to identify emerging food safety risks and to provide early warning signals in a timely manner ...
Wenjuan Mu, G. Kleter, Y. Bouzembrak, Eleonora Dupouy, Lynn J. Frewer, Fadi Naser, Radwan Al Natour, H. J. Marvin   +7 more
semanticscholar   +1 more source

Materials for lithium-ion battery safety

Science Advances, 2018
We summarize the origins of lithium-ion battery safety issues and discuss recent progress in materials design to improve safety. Lithium-ion batteries (LIBs) are considered to be one of the most important energy storage technologies.
Kai Liu, Yayuan Liu, Dingchang Lin, Allen Pei, Yi Cui   +4 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

New England Journal of Medicine, 2019
Background Short‐term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low‐density lipoprotein (LDL) cholesterol.
K. Ray, H. Bays, A. Catapano, N. Lalwani, L. Bloedon, L. Sterling, P. Robinson, C. Ballantyne   +7 more
semanticscholar   +1 more source