This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
The spring 2023 issue of *Patient Safety* is available to read and download at no charge. This issue features four articles that came out of the Patient Safety Authority’s first master class in writing quality improvement studies.
Patient Safety Authority
doaj
Conclusion on the peer review of the pesticide risk assessment of the active substance amitrole [PDF]
The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance amitrole are reported.
European Food Safety Authority
doaj +1 more source
Understanding patient safety performance and educational needs using the ‘Safety-II’ approach for complex systems [PDF]
Participation in projects to improve patient safety is a key component of general practice (GP) specialty training, appraisal and revalidation. Patient safety training priorities for GPs at all career stages are described in the Royal College of General ...
Bowie, Paul +3 more
core +1 more source
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Acknowledgement to Reviewers of Safety in 2016
n ...
Safety Editorial Office
doaj +1 more source
Clarifications on the interpretation of technical issues about the Scientific Opinion on a summary of scientific studies undertaken by the UK Food Standards Agency (FSA) to support a proposed production method for smoked “skin-on” sheep meat [PDF]
No abstract ...
European Food Safety Authority
doaj +1 more source
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Conclusion on the peer review of the pesticide risk assessment of confirmatory data submitted for the active substance lenacil [PDF]
The conclusions of the European Food Safety Authority (EFSA) following the peer review of an initial risk assessment carried out by the competent authority of the rapporteur Member State Belgium, relating to the pesticide active substance lenacil are ...
European Food Safety Authority
doaj +1 more source
Assessing safety climate in acute hospital settings: a systematic review of the adequacy of the psychometric properties of survey measurement tools [PDF]
Background: The perceived importance of safety culture in improving patient safety and its impact on patient outcomes has led to a growing interest in the assessment of safety climate in healthcare organizations; however, the rigour with which safety ...
Alsalem, Gheed +2 more
core +1 more source

