Results 71 to 80 of about 3,131,593 (360)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Three-Dimensional Spectral Element Method Implementation for Evaluating Rooted Soil Behavior in Slope Stability Analysis

Geotechnics
Bioengineering techniques are being increasingly adopted as a sustainable solution to soil slope instability. Despite their recognized benefits, however, the mechanistic contribution of vegetation to slope stability remains inadequately understood due to
Ram Chandra Tiwari, Netra Prakash Bhandary   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Investigation of Shear Strength Reduction Method in Slope Stability of Reinforced Slopes by Anchor and Nail

Buildings
Since the stability of slopes in infrastructures such as road and railroad embankments, excavations, and, in general, earthwork is important, analyzing the stability of these slopes has been one of the main focuses of geotechnical engineers.
SeyedSaber Hosseini, Farshad Astaraki, Seyed Mohammad Reza Imam, Jafar Chalabii, Majid Movahedi Rad   +4 more
doaj   +1 more source

Assessing Information Bias and Food Safety [PDF]

Imperfect information can lead to market failure and be an external factor impacting managers of agribusiness firms. A matrix method approach to content analysis was conducted by independent judges based upon established typologies.
Conley, Dennis M., Wade, Mark A.
core   +1 more source

RESTORATION OF DISTURBED LANDS AS A FACTOR OF ENVIRONMENTAL SAFETY [PDF]

, 2023
I.V. Gorokhova, Л. С. Архипова
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Identifying NPP operator stressors using grounded theory

Scientific Reports
Nuclear power plant (NPP) operators manage crucial decision-making and operational tasks in precarious and complex environments, where psychological stress directly correlates with system safety and operational efficiency.
Ye Wang, Xiliang Tao, Wenqiang Peng, Zhaopeng Liu, Pengcheng Li   +4 more
doaj   +1 more source

Human Factor in Functional Safety

Chemical Engineering Transactions, 2010
Abstract preview not available - see full-text PDF article.
openaire   +2 more sources