Results 81 to 90 of about 3,131,593 (360)

Impurity transport in trapped electron mode driven turbulence

, 2013
Trapped electron mode turbulence is studied by gyrokinetic simulations with the GYRO code and an analytical model including the effect of a poloidally varying electrostatic potential. Its impact on radial transport of high-Z trace impurities close to the
Fülöp, T., Mollén, A., Moradi, S., Pusztai, I.   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Impurity effects on kinetic ballooning instability in high regions of tokamak plasmas

Nuclear Fusion
The impurity effects on kinetic ballooning modes (KBMs) in high $q$ regions of tokamak plasmas are numerically investigated, using a full gyrokinetic description for main and impurity ions. The findings indicate that the critical plasma pressure ratio ${\
J. Li, J.Q. Dong, J.Y. Liu, Z.X. Wang, X.R. Zhang, R. He   +5 more
doaj   +1 more source

SAFETY AND RISK FACTORS FOR THE MORBIDITY AND MORTALITY OF PNEUMONECTOMY: A RETROSPECTIVE 10- YEAR STUDY IN A SINGLE INSTITUTION

, 2021
Joana Rei, Susana Lareiro, Pedro Fernandes, Patrícia Castro, Sara Simões Costa, José Miranda, Luís Vouga, Miguel Guerra   +7 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Influences of Fracturing Fluid Injection on Mechanical Integrity of Cement Sheath under Four Failure Modes

Energies, 2018
The significant decreased wellbore temperature and increased casing pressure during fracturing fluid injection present a big challenge for the mechanical integrity of cement sheath in fracturing wells.
Honglin Xu, Tianshou Ma, Nian Peng, Bin Yang   +3 more
doaj   +1 more source

Ageing test of the ATLAS RPCs at X5-GIF

, 2004
An ageing test of three ATLAS production RPC stations is in course at X5-GIF, the CERN irradiation facility. The chamber efficiencies are monitored using cosmic rays triggered by a scintillator hodoscope.
A. Di Ciaccio, A. Di Simone, A. Nisati, Aielli, B. Liberti, D. Della Volpe, E. Gorini, E. Pastori, F. Conventi, F. Grancagnolo, Fr. Pastore, G. Aielli, G. Carlino, G. Cataldi, G. Chiodini, G. Sekhniaidze, L. Di Stante, M. Alviggi, M. Biglietti, M. Caprio, M. Della Pietra, M. Primavera, P. Camarri, P. Iengo, R. Cardarelli, R. de Asmundis, R. Perrino, R. Santonico, R. Vari, S. Patricelli, S. Spagnolo, S. Veneziano, V. Ammosov, V. Canale, V. Zaets, Yu. Sviridov   +35 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analisis Stabilitas Bendung (Studi Kasus : Bendung Tamiang) [PDF]

, 2016
The objective of This study is to analyze the stability of a weir. The weir that is used to analyze is Tamiang weir. This weir is located in Kotanopan Mandailing Natal District of North Sumatra Province.
', S. (Siswanto), Fauzi, M. '. (Manyuk), Firnanda, A. '. (Afrian)   +2 more
core