Results 91 to 100 of about 20,641,169 (265)
Diversity of Safety Arguments in the Validation of a Sounding Rocket Destruction System [PDF]
, 2001 This work describes an approach for the validation of a software system responsible for the destruction of the sounding rocket VS-40X. The process of validation uses three different techniques ranging from the automatic state exploration to the laborious
Abdala, M.A.D. +2 more
core
Notes on Society History: Pathfinders of System Safety
, 2016 One of the traditional functions of a professional organization such as ours is to provide due recognition and honor to those who have made a significant contribution to the goals of the organization.
Gordon, Rex
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Mechanical Engineering Journal, 2014 Thermal fatigue cracking may initiate at a T-junction pipe where high and low temperature fluids flow in from different directions and mix. Thermal stress is caused by a temperature gradient in a structure and by its variation.
Koji MIYOSHI +2 more
doaj +1 more source
System Safety Bookshelf: Applying Safety Standards to Life-Saving Equipment
, 2019 Elsevier Academic Press has recently published a new safety book titled Safety Risk Management for Medical Devices, written by Bijan Elahi. This book explains how to conduct a risk management program that will show conformance to the FDA safety standards
Ericson, Clif
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System Safety in Healthcare: Lessons Learned From Designing for Safety
, 2021 Designing for safety is a process. When the right process is followed, results can be great, such as eliminating most of the warranty costs. The opposite is also true in the absence of the right process.
Raheja, Dev
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
IEEE Access, 2018 For continuous improvement of productivity, accurate, stable, and reliable control of temperature and humidity is important in industrial production. Accurate prediction of air temperature and humidity can improve the predictability and stability of air ...
Xin Shi +3 more
doaj +1 more source